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Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 11352, updated on 28-Oct-2024

Summary

Official Symbol
Abl2provided by MGI
Official Full Name
ABL proto-oncogene 2, non-receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:87860
See related
Ensembl:ENSMUSG00000026596 AllianceGenome:MGI:87860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arg; Abll
Summary
Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of establishment of T cell polarity; and synapse maturation. Acts upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; diaphragm; hemolymphoid system gland; hindlimb long bone; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 5.8), whole brain E14.5 (RPKM 3.4) and 28 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Abl2 in Genome Data Viewer
Location:
1 G3; 1 67.71 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156386160..156477189)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (156558590..156649619)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene casein kinase 2, alpha 1 polypeptide, pseudogene 3 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02742 Neighboring gene STARR-positive B cell enhancer ABC_E10049 Neighboring gene STARR-positive B cell enhancer ABC_E4362 Neighboring gene STARR-seq mESC enhancer starr_02753 Neighboring gene torsin family 3, member A Neighboring gene STARR-positive B cell enhancer ABC_E4363 Neighboring gene STARR-seq mESC enhancer starr_02755 Neighboring gene FAM20B, glycosaminoglycan xylosylkinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:158640993-158641176

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC169395

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within DN4 thymocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aggressive behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within alpha-beta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within auditory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within circulatory system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exploration behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuroepithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-2 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within substrate-dependent cell migration, cell extension IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase ABL2
Names
Abelson tyrosine-protein kinase 2
Abelson-related gene protein
abelson murine leukemia viral oncogene homolog 2
tyrosine kinase ARG
tyrosine-protein kinase ARG
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
NP_001129576.1
NP_033725.2
XP_006496676.1
XP_006496677.1
XP_006496678.1
XP_006496679.1
XP_006496680.1
XP_006496683.1
XP_006496684.1
XP_006496685.1
XP_011237039.1
XP_011237040.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136104.1NP_001129576.1  tyrosine-protein kinase ABL2 isoform a

    See identical proteins and their annotated locations for NP_001129576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an in-frame segment in the 3' coding region, as compared to variant 2. The resulting isoform (a, also known as 1BLCTS) lacks an internal segment in the C-termius, as compared to isoform b.
    Source sequence(s)
    AC145078, BC137771, CJ171655
    Consensus CDS
    CCDS48404.1
    UniProtKB/TrEMBL
    B2RQ57, B7ZMZ2
    Related
    ENSMUSP00000126181.3, ENSMUST00000166172.9
    Conserved Domains (5) summary
    smart00808
    Location:9591078
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:169262
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:111164
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    smart00221
    Location:288539
    STYKc; Protein kinase; unclassified specificity
    cd05052
    Location:281543
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  2. NM_009595.3NP_033725.2  tyrosine-protein kinase ABL2 isoform b

    See identical proteins and their annotated locations for NP_033725.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (b, also known as 1BLCTL).
    Source sequence(s)
    AC145078, BC137771, CJ171655
    Consensus CDS
    CCDS15393.1
    UniProtKB/Swiss-Prot
    Q4JIM5
    UniProtKB/TrEMBL
    F8VQH0
    Related
    ENSMUSP00000027888.7, ENSMUST00000027888.13
    Conserved Domains (5) summary
    smart00808
    Location:10631182
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:169262
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:111164
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    smart00221
    Location:288539
    STYKc; Protein kinase; unclassified specificity
    cd05052
    Location:281543
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    156386160..156477189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238737.3XP_011237039.1  tyrosine-protein kinase ABL2 isoform X1

    UniProtKB/Swiss-Prot
    Q4JIM5
    Conserved Domains (4) summary
    smart00808
    Location:10621181
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:169262
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:111164
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:281543
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  2. XM_011238738.3XP_011237040.1  tyrosine-protein kinase ABL2 isoform X7

    UniProtKB/TrEMBL
    B7ZMZ2
    Conserved Domains (4) summary
    smart00808
    Location:9581077
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:169262
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:111164
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:281543
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  3. XM_006496615.4XP_006496678.1  tyrosine-protein kinase ABL2 isoform X4

    UniProtKB/Swiss-Prot
    Q4JIM5
    Conserved Domains (4) summary
    smart00808
    Location:10421161
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:148241
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:90143
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:260522
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  4. XM_006496616.4XP_006496679.1  tyrosine-protein kinase ABL2 isoform X5

    UniProtKB/Swiss-Prot
    Q4JIM5
    Conserved Domains (4) summary
    smart00808
    Location:10411160
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:148241
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:90143
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:260522
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  5. XM_006496621.4XP_006496684.1  tyrosine-protein kinase ABL2 isoform X9

    UniProtKB/TrEMBL
    B7ZMZ2
    Conserved Domains (4) summary
    smart00808
    Location:9371056
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:148241
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:90143
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:260522
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  6. XM_006496613.5XP_006496676.1  tyrosine-protein kinase ABL2 isoform X2

    UniProtKB/Swiss-Prot
    Q4JIM5
    Conserved Domains (4) summary
    smart00808
    Location:10481167
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:154247
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:96149
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:266528
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  7. XM_006496614.5XP_006496677.1  tyrosine-protein kinase ABL2 isoform X3

    UniProtKB/Swiss-Prot
    Q4JIM5
    Conserved Domains (4) summary
    smart00808
    Location:10471166
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:154247
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:96149
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:266528
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  8. XM_006496617.5XP_006496680.1  tyrosine-protein kinase ABL2 isoform X6

    UniProtKB/Swiss-Prot
    Q4JIM5
    Conserved Domains (4) summary
    smart00808
    Location:10271146
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:133226
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:75128
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:245507
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  9. XM_006496620.5XP_006496683.1  tyrosine-protein kinase ABL2 isoform X8

    UniProtKB/TrEMBL
    B7ZMZ2
    Conserved Domains (4) summary
    smart00808
    Location:9431062
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:154247
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:96149
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:266528
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  10. XM_006496622.5XP_006496685.1  tyrosine-protein kinase ABL2 isoform X10

    UniProtKB/TrEMBL
    B7ZMZ2
    Conserved Domains (4) summary
    smart00808
    Location:9221041
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:133226
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:75128
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:245507
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase