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FKBP9 FKBP prolyl isomerase 9 [ Homo sapiens (human) ]

Gene ID: 11328, updated on 3-Apr-2024

Summary

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Official Symbol
FKBP9provided by HGNC
Official Full Name
FKBP prolyl isomerase 9provided by HGNC
Primary source
HGNC:HGNC:3725
See related
Ensembl:ENSG00000122642 MIM:616257; AllianceGenome:HGNC:3725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKBP60; FKBP63; PPIase
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 23.7), placenta (RPKM 21.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7p14.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (32957440..33006928)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (33097034..33146534)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (32997052..33046540)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RP9 pseudogene Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:32980636-32981524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:32995899-32996849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18084 Neighboring gene ribosomal protein L7a pseudogene 78 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:33018490-33019689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:33038245-33038830 Neighboring gene RNA, U6 small nuclear 388, pseudogene Neighboring gene 5'-nucleotidase, cytosolic IIIA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18086 Neighboring gene ribosomal protein S29 pseudogene 14 Neighboring gene RNA, 7SL, cytoplasmic 505, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers. Xu H, et al. J Exp Clin Cancer Res, 2020 Feb 28. PMID 32111229, Free PMC Article
  2. Increasing of FKBP9 can predict poor prognosis in patients with prostate cancer. Jiang FN, et al. Pathol Res Pract, 2020 Jan. PMID 31780055
  3. Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. Shadidy M, et al. Biochim Biophys Acta, 1999 Sep 3. PMID 10524204
  4. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. Patterson CE, et al. Genomics, 2002 Jun. PMID 12036304
  5. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Zhang H, et al. Nat Biotechnol, 2003 Jun. PMID 12754519

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increasing of FKBP9 can predict poor prognosis in patients with prostate cancer.
    Title: Increasing of FKBP9 can predict poor prognosis in patients with prostate cancer.
  2. FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers.
    Title: FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126772, MGC138258, DKFZp586B1723

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP9
Names
63 kDa FK506-binding protein
63 kDa FKBP
FK506 binding protein 9, 63 kDa
FK506-binding protein 9
FKBP-63
FKBP-9
PPIase FKBP9
rotamase
NP_001271270.1
NP_001271272.1
NP_009201.2
XP_011513417.1
XP_047275805.1
XP_054213155.1
XP_054213156.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284341.2 → NP_001271270.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001271270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame coding exon in the 5' region compared to variant 1. The resulting isoform (2) is longer with an internal protein segment not found in isoform 1.
    Source sequence(s)
    AK300328, BC099918, DA234297
    Consensus CDS
    CCDS64622.1
    UniProtKB/TrEMBL
    B3KQQ0
    Related
    ENSP00000439250.1, ENST00000538336.5
    Conserved Domains (3) summary
    cd00051
    Location:550 → 611
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:324 → 415
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:548 → 612
    EF-hand_7; EF-hand domain pair

  2. NM_001284343.2 → NP_001271272.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 3

    See identical proteins and their annotated locations for NP_001271272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons at the 5' end and contains an alternate 5' terminal exon, which results in translation initiation from an alternate start codon compared to variant 1. The resulting shorter isoform (3) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC083863, AK293440, BC099918, BQ688269
    Consensus CDS
    CCDS64623.1
    UniProtKB/Swiss-Prot
    O95302
    UniProtKB/TrEMBL
    A7YQ73
    Related
    ENSP00000441317.1, ENST00000490776.3
    Conserved Domains (3) summary
    cd00051
    Location:265 → 326
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:39 → 130
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:263 → 327
    EF-hand_7; EF-hand domain pair

  3. NM_007270.5 → NP_009201.2  peptidyl-prolyl cis-trans isomerase FKBP9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_009201.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    BC099918, BC101723, DA234297
    Consensus CDS
    CCDS5439.1
    UniProtKB/Swiss-Prot
    B3KY35, B7Z1G9, B7Z6H3, O95302, Q2M2A1, Q3MIR7, Q6IN76, Q6P2N1, Q96EX5, Q96IJ9
    UniProtKB/TrEMBL
    B3KQQ0
    Related
    ENSP00000242209.4, ENST00000242209.9
    Conserved Domains (2) summary
    cd00051
    Location:497 → 558
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:47 → 138
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    32957440..33006928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515115.4 → XP_011513417.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X2

    Conserved Domains (1) summary
    pfam00254
    Location:47 → 138
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. XM_047419849.1 → XP_047275805.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    33097034..33146534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357181.1 → XP_054213156.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X2

  2. XM_054357180.1 → XP_054213155.1  peptidyl-prolyl cis-trans isomerase FKBP9 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95302.2 GenPept UniProtKB/Swiss-Prot:O95302

Gene LinkOut

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