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LARP4 La ribonucleoprotein 4 [ Homo sapiens (human) ]

Gene ID: 113251, updated on 5-Mar-2024

Summary

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Official Symbol
LARP4provided by HGNC
Official Full Name
La ribonucleoprotein 4provided by HGNC
Primary source
HGNC:HGNC:24320
See related
Ensembl:ENSG00000161813 MIM:618657; AllianceGenome:HGNC:24320
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP13296
Summary
Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytosol. Colocalizes with cytoplasmic stress granule; cytosolic small ribosomal subunit; and polysome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 13.3), adrenal (RPKM 12.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q13.12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (50400885..50480004)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (50363921..50443087)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50794668..50873787)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984505 Neighboring gene KIAA1586 pseudogene Neighboring gene family with sequence similarity 186 member A Neighboring gene MPRA-validated peak1729 silencer Neighboring gene ribosomal protein L26 pseudogene 33 Neighboring gene small nucleolar RNA, C/D box 133 Neighboring gene uncharacterized LOC124903127 Neighboring gene MPRA-validated peak1730 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6355 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:50923514-50924014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:50924015-50924515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6357 Neighboring gene fragile site, folic acid type, rare, fra(12)(q13.1) Neighboring gene disco interacting protein 2 homolog B Neighboring gene Sharpr-MPRA regulatory region 12282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6360 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51005279-51005780 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:51005781-51006280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6361 Neighboring gene RNA, U6 small nuclear 769, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails. Mattijssen S, et al. Elife, 2020 Aug 3. PMID 32744499, Free PMC Article
  2. Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer. Zhang X, et al. J Clin Lab Anal, 2020 Jul. PMID 32187743, Free PMC Article
  3. La-Related Protein 4 as a Suppressor for Motility of Ovarian Cancer Cells. Egiz M, et al. Tohoku J Exp Med, 2019 Jan. PMID 30686809
  4. circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma. Chen Z, et al. Cancer Sci, 2019 Feb. PMID 30520539, Free PMC Article
  5. Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis. Zou T, et al. Eur Rev Med Pharmacol Sci, 2018 Nov. PMID 30468459

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.
    Title: LARP4 is an RNA-binding protein that binds nuclear-encoded mitochondrial mRNAs to promote mitochondrial function.
  2. CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.
    Title: CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.
  3. Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
    Title: Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer.
  4. Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.
    Title: Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.
  5. Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.
    Title: Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.
  6. Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails.
    Title: Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails.
  7. Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.
    Title: Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma.
  8. Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.
    Title: Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.
  9. LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
    Title: LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
  10. These results indicated that circLARP4 expression was lower and highlighted that circLARP4 was identified as a potential biomarker of ovarian cancer prognosis.
    Title: Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC74631, DKFZp686E039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
la-related protein 4
Names
La ribonucleoprotein domain family member 4
c-Mpl binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170803.2 → NP_001164274.1  la-related protein 4 isoform d

    See identical proteins and their annotated locations for NP_001164274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform d), compared to isoform a.
    Source sequence(s)
    AC090058
    UniProtKB/TrEMBL
    Q6P4E2, Q8TBL5
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199 → 269
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001170804.2 → NP_001164275.1  la-related protein 4 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (e) has a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC090058, AW002420, AY004310, BC063479, DB061954
    Consensus CDS
    CCDS53789.1
    UniProtKB/TrEMBL
    Q6P4E2
    Related
    ENSP00000429781.1, ENST00000522085.5
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199 → 275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  3. NM_001170808.2 → NP_001164279.1  la-related protein 4 isoform f

    See identical proteins and their annotated locations for NP_001164279.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform f), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS53790.1
    UniProtKB/Swiss-Prot
    Q71RC2
    UniProtKB/TrEMBL
    Q6P4E2, Q8TBL5
    Related
    ENSP00000293618.8, ENST00000293618.12
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199 → 275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  4. NM_001330415.2 → NP_001317344.1  la-related protein 4 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform g), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS81690.1
    UniProtKB/Swiss-Prot
    Q71RC2
    Related
    ENSP00000415464.3, ENST00000429001.7

  5. NM_001352304.2 → NP_001339233.1  la-related protein 4 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 28, encodes isoform h.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS86300.1
    UniProtKB/TrEMBL
    Q6P4E2, Q96J85
    Related
    ENSP00000430851.1, ENST00000518561.5
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  6. NM_001352305.2 → NP_001339234.1  la-related protein 4 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:125 → 199
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:204 → 280
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  7. NM_001352306.2 → NP_001339235.1  la-related protein 4 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:128 → 202
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:207 → 265
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. NM_001352307.2 → NP_001339236.1  la-related protein 4 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199 → 257
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. NM_001352308.2 → NP_001339237.1  la-related protein 4 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:126 → 200
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:205 → 275
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. NM_001352309.2 → NP_001339238.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 14-18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  11. NM_001352310.2 → NP_001339239.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 13 and 15-18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  12. NM_001352311.2 → NP_001339240.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 13, 14, and 16-18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  13. NM_001352312.2 → NP_001339241.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 13-15. 17, and 18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  14. NM_001352313.2 → NP_001339242.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 13-16 and 18, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  15. NM_001352314.2 → NP_001339243.1  la-related protein 4 isoform m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 13-17, encodes isoform m.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  16. NM_001352315.2 → NP_001339244.1  la-related protein 4 isoform n

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:119 → 193
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:198 → 268
    RRM_SF; RNA recognition motif (RRM) superfamily

  17. NM_001352316.2 → NP_001339245.1  la-related protein 4 isoform o

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform o.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:129 → 199
    RRM_SF; RNA recognition motif (RRM) superfamily

  18. NM_001352317.2 → NP_001339246.1  la-related protein 4 isoform o

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform o.
    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:129 → 199
    RRM_SF; RNA recognition motif (RRM) superfamily

  19. NM_001352318.2 → NP_001339247.1  la-related protein 4 isoform p

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  20. NM_001352319.2 → NP_001339248.1  la-related protein 4 isoform q

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:49 → 123
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:128 → 198
    RRM_SF; RNA recognition motif (RRM) superfamily

  21. NM_001352320.2 → NP_001339249.1  la-related protein 4 isoform r

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:129 → 199
    RRM_SF; RNA recognition motif (RRM) superfamily

  22. NM_001352321.2 → NP_001339250.1  la-related protein 4 isoform s

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199 → 275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  23. NM_001352322.2 → NP_001339251.1  la-related protein 4 isoform t

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199 → 269
    RRM_SF; RNA recognition motif (RRM) superfamily

  24. NM_001352323.2 → NP_001339252.1  la-related protein 4 isoform u

    Status: VALIDATED

    Source sequence(s)
    AC090058
    Conserved Domains (3) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199 → 275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    pfam14179
    Location:292 → 360
    YppG; YppG-like protein

  25. NM_001352324.2 → NP_001339253.1  la-related protein 4 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variant 7, encodes isoform h.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS86300.1
    UniProtKB/TrEMBL
    Q6P4E2, Q96J85
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  26. NM_001352325.2 → NP_001339254.1  la-related protein 4 isoform v

    Status: VALIDATED

    Source sequence(s)
    AC090058
    UniProtKB/TrEMBL
    Q6P4E2
    Conserved Domains (3) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199 → 275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)
    pfam14179
    Location:292 → 360
    YppG; YppG-like protein

  27. NM_001352326.2 → NP_001339255.1  la-related protein 4 isoform w

    Status: VALIDATED

    Source sequence(s)
    AC090058
    UniProtKB/TrEMBL
    Q6P4E2
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199 → 269
    RRM_SF; RNA recognition motif (RRM) superfamily

  28. NM_052879.5 → NP_443111.4  la-related protein 4 isoform a

    See identical proteins and their annotated locations for NP_443111.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS41782.1
    UniProtKB/Swiss-Prot
    A8K6T1, E9PDG5, G3XAA8, G5E976, Q5CZ97, Q6ZV14, Q71RC2, Q96NF9
    Related
    ENSP00000381490.2, ENST00000398473.7
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:199 → 275
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  29. NM_199188.3 → NP_954658.2  la-related protein 4 isoform b

    See identical proteins and their annotated locations for NP_954658.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS44879.2
    UniProtKB/Swiss-Prot
    Q71RC2
    Related
    ENSP00000429077.1, ENST00000518444.5
    Conserved Domains (2) summary
    cd08035
    Location:119 → 193
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:198 → 274
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  30. NM_199190.3 → NP_954660.1  la-related protein 4 isoform c

    See identical proteins and their annotated locations for NP_954660.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC090058
    Consensus CDS
    CCDS44880.1
    UniProtKB/Swiss-Prot
    Q71RC2
    Related
    ENSP00000340901.5, ENST00000347328.9
    Conserved Domains (2) summary
    cd08035
    Location:120 → 194
    LARP_4; La RNA-binding domain of La-related protein 4
    cl17169
    Location:199 → 269
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    50400885..50480004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428212.1 → XP_047284168.1  la-related protein 4 isoform X9

  2. XM_047428213.1 → XP_047284169.1  la-related protein 4 isoform X9

  3. XM_047428208.1 → XP_047284164.1  la-related protein 4 isoform X7

  4. XM_047428209.1 → XP_047284165.1  la-related protein 4 isoform X8

  5. XM_047428220.1 → XP_047284176.1  la-related protein 4 isoform X10

  6. XM_047428227.1 → XP_047284183.1  la-related protein 4 isoform X14

  7. XM_047428230.1 → XP_047284186.1  la-related protein 4 isoform X17

  8. XM_047428218.1 → XP_047284174.1  la-related protein 4 isoform X9

  9. XM_047428210.1 → XP_047284166.1  la-related protein 4 isoform X9

  10. XM_047428216.1 → XP_047284172.1  la-related protein 4 isoform X9

  11. XM_047428202.1 → XP_047284158.1  la-related protein 4 isoform X1

  12. XM_047428205.1 → XP_047284161.1  la-related protein 4 isoform X4

  13. XM_047428204.1 → XP_047284160.1  la-related protein 4 isoform X3

  14. XM_047428222.1 → XP_047284178.1  la-related protein 4 isoform X11

  15. XM_047428203.1 → XP_047284159.1  la-related protein 4 isoform X2

  16. XM_047428207.1 → XP_047284163.1  la-related protein 4 isoform X6

  17. XM_047428206.1 → XP_047284162.1  la-related protein 4 isoform X5

  18. XM_047428223.1 → XP_047284179.1  la-related protein 4 isoform X12

  19. XM_047428211.1 → XP_047284167.1  la-related protein 4 isoform X9

  20. XM_047428219.1 → XP_047284175.1  la-related protein 4 isoform X9

  21. XM_047428215.1 → XP_047284171.1  la-related protein 4 isoform X9

  22. XM_047428224.1 → XP_047284180.1  la-related protein 4 isoform X9

  23. XM_047428226.1 → XP_047284182.1  la-related protein 4 isoform X13

  24. XM_047428225.1 → XP_047284181.1  la-related protein 4 isoform X9

  25. XM_047428214.1 → XP_047284170.1  la-related protein 4 isoform X9

  26. XM_047428228.1 → XP_047284184.1  la-related protein 4 isoform X15

  27. XM_047428229.1 → XP_047284185.1  la-related protein 4 isoform X16

  28. XM_047428233.1 → XP_047284189.1  la-related protein 4 isoform X19

  29. XM_047428231.1 → XP_047284187.1  la-related protein 4 isoform X18

  30. XM_017018751.3 → XP_016874240.1  la-related protein 4 isoform X9

    UniProtKB/Swiss-Prot
    Q71RC2
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

  31. XM_047428217.1 → XP_047284173.1  la-related protein 4 isoform X9

  32. XM_017018753.3 → XP_016874242.1  la-related protein 4 isoform X9

    UniProtKB/Swiss-Prot
    Q71RC2
    Conserved Domains (2) summary
    cd08035
    Location:50 → 124
    LARP_4; La RNA-binding domain of La-related protein 4
    cd12707
    Location:129 → 205
    RRM_LARP4; RNA recognition motif in vertebrate La-related protein 4 (LARP4)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    50363921..50443087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370956.1 → XP_054226931.1  la-related protein 4 isoform X9

  2. XM_054370958.1 → XP_054226933.1  la-related protein 4 isoform X9

  3. XM_054370957.1 → XP_054226932.1  la-related protein 4 isoform X9

  4. XM_054370959.1 → XP_054226934.1  la-related protein 4 isoform X9

  5. XM_054370960.1 → XP_054226935.1  la-related protein 4 isoform X9

  6. XM_054370951.1 → XP_054226926.1  la-related protein 4 isoform X7

  7. XM_054370952.1 → XP_054226927.1  la-related protein 4 isoform X8

  8. XM_054370965.1 → XP_054226940.1  la-related protein 4 isoform X10

  9. XM_054370971.1 → XP_054226946.1  la-related protein 4 isoform X14

  10. XM_054370974.1 → XP_054226949.1  la-related protein 4 isoform X17

  11. XM_054370953.1 → XP_054226928.1  la-related protein 4 isoform X9

  12. XM_054370962.1 → XP_054226937.1  la-related protein 4 isoform X9

  13. XM_054370945.1 → XP_054226920.1  la-related protein 4 isoform X1

  14. XM_054370948.1 → XP_054226923.1  la-related protein 4 isoform X4

  15. XM_054370947.1 → XP_054226922.1  la-related protein 4 isoform X3

  16. XM_054370966.1 → XP_054226941.1  la-related protein 4 isoform X11

  17. XM_054370946.1 → XP_054226921.1  la-related protein 4 isoform X2

  18. XM_054370950.1 → XP_054226925.1  la-related protein 4 isoform X6

  19. XM_054370949.1 → XP_054226924.1  la-related protein 4 isoform X5

  20. XM_054370967.1 → XP_054226942.1  la-related protein 4 isoform X12

  21. XM_054370954.1 → XP_054226929.1  la-related protein 4 isoform X9

  22. XM_054370964.1 → XP_054226939.1  la-related protein 4 isoform X9

  23. XM_054370968.1 → XP_054226943.1  la-related protein 4 isoform X9

  24. XM_054370970.1 → XP_054226945.1  la-related protein 4 isoform X13

  25. XM_054370969.1 → XP_054226944.1  la-related protein 4 isoform X9

  26. XM_054370961.1 → XP_054226936.1  la-related protein 4 isoform X9

  27. XM_054370972.1 → XP_054226947.1  la-related protein 4 isoform X15

  28. XM_054370973.1 → XP_054226948.1  la-related protein 4 isoform X16

  29. XM_054370976.1 → XP_054226951.1  la-related protein 4 isoform X19

  30. XM_054370975.1 → XP_054226950.1  la-related protein 4 isoform X18

  31. XM_054370955.1 → XP_054226930.1  la-related protein 4 isoform X9

  32. XM_054370963.1 → XP_054226938.1  la-related protein 4 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q71RC2.3 GenPept UniProtKB/Swiss-Prot:Q71RC2

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