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MIR12136 microRNA 12136 [ Homo sapiens (human) ]

Gene ID: 113219467, updated on 2-Nov-2024

Summary

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Official Symbol
MIR12136provided by HGNC
Official Full Name
microRNA 12136provided by HGNC
Primary source
HGNC:HGNC:54043
See related
miRBase:MI0039740; AllianceGenome:HGNC:54043
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR12136 in Genome Data Viewer
Location:
1p36.33
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (632615..632685, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (567995..568065, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:564533-565276 Neighboring gene MT-ND1 pseudogene 23 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:565277-566020 Neighboring gene MT-ND2 pseudogene 28 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:566191-566791 Neighboring gene MT-CO1 pseudogene 12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:567218-567827 Neighboring gene MT-CO2 pseudogene 12 Neighboring gene MT-ATP8 pseudogene 1 Neighboring gene MT-ATP6 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel point mutation in the mitochondrial tRNA(Ser(UCN)) gene detected in a family with MERRF/MELAS overlap syndrome. Nakamura M, et al. Biochem Biophys Res Commun, 1995 Sep 5. PMID 7669057
  2. Evolution of microRNA in primates. McCreight JC, et al. PLoS One, 2017. PMID 28640911, Free PMC Article
  3. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • hsa-mir-12136
  • tRNA<up>Ser(UNC)</up>

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables triplet codon-amino acid adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_162149.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC114498

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    632615..632685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases