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MIR10524 microRNA 10524 [ Homo sapiens (human) ]

Gene ID: 113218491, updated on 10-Oct-2023

Summary

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Official Symbol
MIR10524provided by HGNC
Official Full Name
microRNA 10524provided by HGNC
Primary source
HGNC:HGNC:54014
See related
miRBase:MI0033671; AllianceGenome:HGNC:54014
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR10524 in Genome Data Viewer
Location:
6q14.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (78539263..78539309, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (79716647..79716693, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (79248980..79249026, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901493 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95327 Neighboring gene ribosomal protein S6 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17344 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:78425972-78426700 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:78426701-78427427 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:78427428-78428155 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:78435339-78436048 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:78436049-78436759 Neighboring gene meiotic double-stranded break formation protein 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95486 Neighboring gene uncharacterized LOC105377865 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95584 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95703 Neighboring gene NANOG hESC enhancer GRCh37_chr6:78803625-78804263 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95763 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95771 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95804 Neighboring gene NANOG hESC enhancer GRCh37_chr6:78901647-78902148 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_95852 and experimental_95858 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95876 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_95967 Neighboring gene MPRA-validated peak5909 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr6:79289792-79290318 Neighboring gene uncharacterized LOC107986613 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:79568400-79568966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24765 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:79577455-79578055 Neighboring gene interleukin 1 receptor associated kinase 1 binding protein 1 Neighboring gene tRNA-Phe (anticodon GAA) 8-1 Neighboring gene pleckstrin homology domain interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective microRNA-Offset RNA expression in human embryonic stem cells. Asikainen S, et al. PLoS One, 2015. PMID 25822230, Free PMC Article
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • hsa-mir-10524

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_162115.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL121962

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    78539263..78539309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    79716647..79716693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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