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ECD ecdysoneless cell cycle regulator [ Homo sapiens (human) ]

Gene ID: 11319, updated on 5-Mar-2024

Summary

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Official Symbol
ECDprovided by HGNC
Official Full Name
ecdysoneless cell cycle regulatorprovided by HGNC
Primary source
HGNC:HGNC:17029
See related
Ensembl:ENSG00000122882 MIM:616464; AllianceGenome:HGNC:17029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCR2; SGT1; HSGT1
Summary
Enables histone acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 14.0), thyroid (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ECD in Genome Data Viewer
Location:
10q22.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73133668..73168095, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74005060..74039488, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (74893426..74927853, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74778077-74778636 Neighboring gene prolyl 4-hydroxylase subunit alpha 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3554 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74856005-74856760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3555 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:74866945-74867185 Neighboring gene nudix hydrolase 13 Neighboring gene small nucleolar RNA, H/ACA box 11F Neighboring gene uncharacterized LOC124902452 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74927585-74928184 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74928785-74929383 Neighboring gene family with sequence similarity 149 member B1 Neighboring gene uncharacterized LOC105378358 Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism. Mohapatra BC, et al. Mol Cancer Res, 2022 Sep 2. PMID 35675041, Free PMC Article
  2. Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis. Dey P, et al. Clin Cancer Res, 2012 Nov 15. PMID 22977192, Free PMC Article
  3. Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients. Zhao X, et al. Breast Cancer Res Treat, 2012 Jul. PMID 22270930, Free PMC Article
  4. The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells. Bele A, et al. Cell Cycle, 2015. PMID 25616580, Free PMC Article
  5. Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation. Kim JH, et al. Biol Chem, 2010 Jan. PMID 19919181, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism.
    Title: Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism.
  2. ECD promotes gastric cancer cell invasion and metastasis by preventing E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation.
    Title: ECD promotes gastric cancer metastasis by blocking E3 ligase ZFP91-mediated hnRNP F ubiquitination and degradation.
  3. The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function.
    Title: A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression.
  4. Ecdysoneless and H-Ras expressing human mammary epithelial cells form tumors in NOD/SCID mice.
    Title: The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells.
  5. TXNIP has a role in the pathway involving hEcd to increase p53 stability and activity
    Title: TXNIP interacts with hEcd to increase p53 stability and activity.
  6. Ecd is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells.
    Title: Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis.
  7. Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients.
    Title: Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/neu-overexpressing breast cancer patients.
  8. Ecd localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd functions as a transcriptional regulator.
    Title: Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: P4HA1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone acetyltransferase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein ecdysoneless homolog
Names
ecdysoneless homolog
human suppressor of GCR two
protein SGT1
suppressor of GCR2
suppressor of S. cerevisiae gcr2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135752.1 → NP_001129224.1  protein ecdysoneless homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon compared to variant 1 resulting in a shorter protein isoform (2).
    Source sequence(s)
    AK225519, AK315711, BC103720, BM763002
    Consensus CDS
    CCDS44434.1
    UniProtKB/TrEMBL
    B3KMT5
    Related
    ENSP00000401566.1, ENST00000430082.6
    Conserved Domains (1) summary
    pfam07093
    Location:14 → 630
    SGT1; SGT1 protein

  2. NM_001135753.1 → NP_001129225.1  protein ecdysoneless homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant includes an additional in-frame coding exon compared to variant 1 resulting in a longer protein isoform (3).
    Source sequence(s)
    AK225519, BC000721, BC103720, BM763002
    Consensus CDS
    CCDS44433.1
    UniProtKB/TrEMBL
    B3KMT5
    Related
    ENSP00000395786.1, ENST00000454759.6
    Conserved Domains (1) summary
    pfam07093
    Location:14 → 554
    SGT1; SGT1 protein

  3. NM_007265.3 → NP_009196.1  protein ecdysoneless homolog isoform 1

    See identical proteins and their annotated locations for NP_009196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a more abundant transcript and encodes isoform 1.
    Source sequence(s)
    AC016394, BC103720, D88208
    Consensus CDS
    CCDS7321.1
    UniProtKB/Swiss-Prot
    C9JX46, E9PAW8, O95905
    UniProtKB/TrEMBL
    B3KMT5
    Related
    ENSP00000362070.4, ENST00000372979.9
    Conserved Domains (1) summary
    pfam07093
    Location:14 → 597
    SGT1; SGT1 protein

RNA

  1. NR_024203.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) omits the first coding exon and an additional coding exon compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    BC000721, BC103720, BM763002
    Related
    ENST00000484976.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73133668..73168095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74005060..74039488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95905.1 GenPept UniProtKB/Swiss-Prot:O95905

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