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PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing [ Apteryx rowi (Okarito brown kiwi) ]

Gene ID: 112977045, updated on 15-Mar-2024

Summary

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Gene symbol
PIKFYVE
Gene description
phosphoinositide kinase, FYVE-type zinc finger containing
See related
Ensembl:ENSARWG00000003327
Gene type
protein coding
RefSeq status
MODEL
Organism
Apteryx rowi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Palaeognathae; Apterygiformes; Apterygidae; Apteryx
Orthologs
human mouse all
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Genomic context

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See PIKFYVE in Genome Data Viewer
Location:
chromosome: Un
Exon count:
48
Annotation release Status Assembly Chr Location
100 current aptRow1 (GCF_003343035.1) Unplaced Scaffold NW_020447419.1 (4169629..4266254, complement)

NW_020447419.1Genomic Context describing neighboring genes Neighboring gene microtubule associated protein 2 Neighboring gene parathyroid hormone 2 receptor Neighboring gene uncharacterized LOC112977091 Neighboring gene chromosome unknown C2orf80 homolog Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene shugoshin 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020447419 Unplaced Scaffold Reference aptRow1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 3-phosphate 5-kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Apteryx rowi Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference aptRow1

Genomic

  1. NW_020447419.1 Reference aptRow1

    Range
    4169629..4266254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026088921.1 → XP_025944706.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    Related
    ENSARWP00000004889.1, ENSARWT00000005619.1
    Conserved Domains (4) summary
    cd00139
    Location:1796 → 2109
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:628 → 888
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:367 → 448
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:164 → 225
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  2. XM_026088925.1 → XP_025944710.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    Related
    ENSARWP00000004890.1, ENSARWT00000005620.1
    Conserved Domains (4) summary
    cd00139
    Location:1740 → 2053
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:572 → 832
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:367 → 448
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:164 → 225
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  3. XM_026088935.1 → XP_025944720.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    Conserved Domains (4) summary
    cd03334
    Location:628 → 888
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:367 → 448
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:164 → 225
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl02572
    Location:1837 → 2050
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

  4. XM_026088946.1 → XP_025944731.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

    Conserved Domains (3) summary
    cd03334
    Location:628 → 888
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:367 → 448
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:164 → 225
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  5. XM_026088958.1 → XP_025944743.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    Conserved Domains (3) summary
    cd03334
    Location:628 → 888
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:367 → 448
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:164 → 225
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

  6. XM_026088968.1 → XP_025944753.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

    Conserved Domains (2) summary
    cd04448
    Location:420 → 501
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:217 → 278
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins

RNA

  1. XR_003257288.1 RNA Sequence

  2. XR_003257290.1 RNA Sequence

  3. XR_003257287.1 RNA Sequence

  4. XR_003257300.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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