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NRG1 neuregulin 1 [ Puma concolor (puma) ]

Gene ID: 112869874, updated on 15-Mar-2024

Summary

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Gene symbol
NRG1
Gene description
neuregulin 1
Gene type
protein coding
RefSeq status
MODEL
Organism
Puma concolor
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma
Orthologs
human mouse all
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Genomic context

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See NRG1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
20
Annotation release Status Assembly Chr Location
100 current PumCon1.0 (GCF_003327715.1) Unplaced Scaffold NW_020340027.1 (7692212..7917543, complement)

NW_020340027.1Genomic Context describing neighboring genes Neighboring gene MAK16 homolog Neighboring gene fucosyltransferase 10 Neighboring gene mitochondrial import inner membrane translocase subunit TIM16 pseudogene Neighboring gene RNA-binding protein EWS pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020340027 Unplaced Scaffold Reference PumCon1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemorepellent activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pro-neuregulin-1, membrane-bound isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Puma concolor Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference PumCon1.0 Primary Assembly

Genomic

  1. NW_020340027.1 Reference PumCon1.0 Primary Assembly

    Range
    7692212..7917543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025932902.1 → XP_025788687.1  pro-neuregulin-1, membrane-bound isoform isoform X6

    UniProtKB/TrEMBL
    A0A6P6IKP4
    Conserved Domains (4) summary
    PHA03099
    Location:147 → 236
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:155 → 185
    EGF; EGF-like domain
    pfam02158
    Location:229 → 583
    Neuregulin; Neuregulin family
    cd05895
    Location:36 → 128
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

  2. XM_025932901.1 → XP_025788686.1  pro-neuregulin-1, membrane-bound isoform isoform X5

    UniProtKB/TrEMBL
    A0A6P6IKC1
    Conserved Domains (4) summary
    PHA03099
    Location:181 → 270
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:189 → 219
    EGF; EGF-like domain
    pfam02158
    Location:263 → 617
    Neuregulin; Neuregulin family
    cd05895
    Location:36 → 128
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

  3. XM_025932900.1 → XP_025788685.1  pro-neuregulin-1, membrane-bound isoform isoform X4

    UniProtKB/TrEMBL
    A0A6P6IKF0
    Conserved Domains (3) summary
    pfam00008
    Location:189 → 219
    EGF; EGF-like domain
    pfam02158
    Location:271 → 625
    Neuregulin; Neuregulin family
    cd05895
    Location:36 → 128
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

  4. XM_025932898.1 → XP_025788683.1  pro-neuregulin-1, membrane-bound isoform isoform X2

    UniProtKB/TrEMBL
    A0A6P6IP51
    Conserved Domains (3) summary
    cd05895
    Location:52 → 126
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
    pfam00008
    Location:189 → 219
    EGF; EGF-like domain
    pfam02158
    Location:257 → 649
    Neuregulin; Neuregulin family

  5. XM_025932899.1 → XP_025788684.1  pro-neuregulin-1, membrane-bound isoform isoform X3

    UniProtKB/TrEMBL
    A0A6P6ILI0
    Conserved Domains (4) summary
    PHA03099
    Location:181 → 273
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    cd00054
    Location:189 → 221
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02158
    Location:266 → 620
    Neuregulin; Neuregulin family
    cd05895
    Location:36 → 128
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

  6. XM_025932897.1 → XP_025788682.1  pro-neuregulin-1, membrane-bound isoform isoform X1

    UniProtKB/TrEMBL
    A0A6P6IKN8
    Conserved Domains (2) summary
    pfam00008
    Location:245 → 275
    EGF; EGF-like domain
    pfam02158
    Location:327 → 681
    Neuregulin; Neuregulin family

  7. XM_025932904.1 → XP_025788689.1  pro-neuregulin-1, membrane-bound isoform isoform X8

    UniProtKB/TrEMBL
    A0A6P6ILI4
    Conserved Domains (3) summary
    PHA03099
    Location:28 → 117
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    pfam00008
    Location:36 → 66
    EGF; EGF-like domain
    pfam02158
    Location:110 → 464
    Neuregulin; Neuregulin family

  8. XM_025932905.1 → XP_025788690.1  pro-neuregulin-1, membrane-bound isoform isoform X9

    UniProtKB/TrEMBL
    A0A6P6IKF6
    Conserved Domains (4) summary
    PHA03099
    Location:181 → 273
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    cd00054
    Location:189 → 221
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02158
    Location:266 → 423
    Neuregulin; Neuregulin family
    cd05895
    Location:36 → 128
    Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1

  9. XM_025932903.1 → XP_025788688.1  pro-neuregulin-1, membrane-bound isoform isoform X7

    UniProtKB/TrEMBL
    A0A6P6IP56
    Conserved Domains (1) summary
    pfam02158
    Location:327 → 484
    Neuregulin; Neuregulin family

  10. XM_025932906.1 → XP_025788691.1  pro-neuregulin-1, membrane-bound isoform isoform X10

    UniProtKB/TrEMBL
    A0A6P6IKC6
    Conserved Domains (3) summary
    pfam00008
    Location:36 → 66
    EGF; EGF-like domain
    pfam02158
    Location:81 → 270
    Neuregulin; Neuregulin family
    cl28647
    Location:2 → 69
    PHA02887; EGF-like protein; Provisional
Nucleotide Protein
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