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ERBB4 erb-b2 receptor tyrosine kinase 4 [ Puma concolor (puma) ]

Gene ID: 112866849, updated on 11-Apr-2024

Summary

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Gene symbol
ERBB4
Gene description
erb-b2 receptor tyrosine kinase 4
Gene type
protein coding
RefSeq status
MODEL
Organism
Puma concolor
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma
Orthologs
human mouse all
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Genomic context

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See ERBB4 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
28
Annotation release Status Assembly Chr Location
100 current PumCon1.0 (GCF_003327715.1) Unplaced Scaffold NW_020338243.1 (198102850..198843276, complement)

NW_020338243.1Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene small nucleolar RNA U3 Neighboring gene TSR3 ribosome maturation factor Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene IKAROS family zinc finger 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020338243 Unplaced Scaffold Reference PumCon1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Puma concolor Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference PumCon1.0 Primary Assembly

Genomic

  1. NW_020338243.1 Reference PumCon1.0 Primary Assembly

    Range
    198102850..198843276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025929814.1 → XP_025785599.1  receptor tyrosine-protein kinase erbB-4

    UniProtKB/TrEMBL
    A0A6P6ID11
    Conserved Domains (5) summary
    cd12092
    Location:651 → 694
    TM_ErbB4; Transmembrane domain of ErbB4, a Protein Tyrosine Kinase
    pfam00757
    Location:180 → 326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:49 → 161
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:496 → 628
    GF_recep_IV; Growth factor receptor domain IV
    cl21453
    Location:719 → 997
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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