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CBL Cbl proto-oncogene [ Canis lupus dingo (dingo) ]

Gene ID: 112671204, updated on 10-Oct-2024

Summary

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Gene symbol
CBL
Gene description
Cbl proto-oncogene
See related
Ensembl:ENSCAFG00020012603
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus dingo (sub-species: dingo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CBL in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
102 current ASM325472v2 (GCF_003254725.2) 5 NC_064247.1 (14611389..14689548, complement)
101 previous assembly UNSW_AlpineDingo_1.0 (GCF_012295265.1) 5 Unlocalized Scaffold NW_023365093.1 (14777738..14856255, complement)

Chromosome 5 - NC_064247.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 26 Neighboring gene melanoma cell adhesion molecule Neighboring gene small nucleolar RNA SNORA19 Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene NHERF family PDZ scaffold protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus dingo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM325472v2

Genomic

  1. NC_064247.1 Reference ASM325472v2

    Range
    14611389..14689548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035716791.2 → XP_035572684.2  E3 ubiquitin-protein ligase CBL isoform X1

    UniProtKB/TrEMBL
    A0A8C0KHM7, A0A8I3MBU4, A0A8P0TCM4

  2. XM_035716792.2 → XP_035572685.1  E3 ubiquitin-protein ligase CBL isoform X3

    UniProtKB/TrEMBL
    A0A8C0T9I9
    Conserved Domains (4) summary
    cd09920
    Location:96 → 192
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:702 → 741
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:202 → 267
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02761
    Location:19 → 102
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  3. XM_025465251.3 → XP_025321036.1  E3 ubiquitin-protein ligase CBL isoform X2

    UniProtKB/TrEMBL
    A0A8C0T9I9
    Conserved Domains (5) summary
    cd09920
    Location:151 → 247
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:757 → 796
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:257 → 322
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:1 → 67
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:74 → 157
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  4. XM_049109877.1 → XP_048965834.1  E3 ubiquitin-protein ligase CBL isoform X2

Nucleotide Protein
Heading Accession and Version

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