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CD74 CD74 molecule [ Canis lupus dingo (dingo) ]

Gene ID: 112651425, updated on 15-Mar-2024

Summary

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Gene symbol
CD74
Gene description
CD74 molecule
See related
Ensembl:ENSCAFG00020023646
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus dingo (sub-species: dingo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CD74 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
102 current ASM325472v2 (GCF_003254725.2) 4 NC_064246.1 (59117764..59140435)
101 previous assembly UNSW_AlpineDingo_1.0 (GCF_012295265.1) 4 Unlocalized Scaffold NW_023365084.1 (59114762..59123435)

Chromosome 4 - NC_064246.1Genomic Context describing neighboring genes Neighboring gene N-deacetylase and N-sulfotransferase 1 Neighboring gene glutathione S-transferase P-like Neighboring gene ribosomal protein S14 Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene uncharacterized LOC125754989 Neighboring gene uncharacterized LOC112651280

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables macrophage migration inhibitory factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of type 2 immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein trimerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
HLA class II histocompatibility antigen gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus dingo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM325472v2

Genomic

  1. NC_064246.1 Reference ASM325472v2

    Range
    59117764..59140435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025434671.3 → XP_025290456.1  HLA class II histocompatibility antigen gamma chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0LI20, A0A8C0LIF5, A0A8C0S1D1, A0A8I3N490
    Related
    ENSCAFP00020030316.1
    Conserved Domains (3) summary
    cd00191
    Location:196 → 255
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam08831
    Location:120 → 188
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerisation domain
    pfam09307
    Location:1 → 113
    MHC2-interact; CLIP, MHC2 interacting

  2. XM_025434672.3 → XP_025290457.1  HLA class II histocompatibility antigen gamma chain isoform X2

    UniProtKB/TrEMBL
    A0A8C0LGA4, A0A8I3RTM7, A0A8P0NJF5
    Related
    ENSCAFP00020030319.1
    Conserved Domains (2) summary
    pfam08831
    Location:120 → 188
    MHCassoc_trimer; Class II MHC-associated invariant chain trimerisation domain
    pfam09307
    Location:1 → 113
    MHC2-interact; CLIP, MHC2 interacting
Nucleotide Protein
Heading Accession and Version

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