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AGRN agrin [ Canis lupus dingo (dingo) ]

Gene ID: 112647029, updated on 10-Oct-2024

Summary

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Gene symbol
AGRN
Gene description
agrin
See related
Ensembl:ENSCAFG00020011666
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus dingo (sub-species: dingo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See AGRN in Genome Data Viewer
Location:
chromosome: 5
Exon count:
56
Annotation release Status Assembly Chr Location
102 current ASM325472v2 (GCF_003254725.2) 5 NC_064247.1 (56372376..56421995)
101 previous assembly UNSW_AlpineDingo_1.0 (GCF_012295265.1) 5 Unlocalized Scaffold NW_023365093.1 (56668199..56702097)

Chromosome 5 - NC_064247.1Genomic Context describing neighboring genes Neighboring gene hes family bHLH transcription factor 4 Neighboring gene ISG15 ubiquitin like modifier Neighboring gene ring finger protein 223 Neighboring gene chromosome 5 C1orf159 homolog Neighboring gene uncharacterized LOC118354692

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
agrin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus dingo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM325472v2

Genomic

  1. NC_064247.1 Reference ASM325472v2

    Range
    56372376..56421995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_049110449.1 → XP_048966406.1  agrin isoform X1

  2. XM_049110452.1 → XP_048966409.1  agrin isoform X4

  3. XM_049110450.1 → XP_048966407.1  agrin isoform X2

  4. XM_049110451.1 → XP_048966408.1  agrin isoform X3

  5. XM_049110453.1 → XP_048966410.1  agrin isoform X5

  6. XM_049110456.1 → XP_048966413.1  agrin isoform X8

  7. XM_049110458.1 → XP_048966415.1  agrin isoform X10

  8. XM_049110457.1 → XP_048966414.1  agrin isoform X9

  9. XM_049110459.1 → XP_048966416.1  agrin isoform X11

  10. XM_049110460.1 → XP_048966417.1  agrin isoform X12

    UniProtKB/TrEMBL
    A0A8C0RWB1

  11. XM_049110462.1 → XP_048966419.1  agrin isoform X16

  12. XM_025427605.3 → XP_025283390.1  agrin isoform X13

    UniProtKB/TrEMBL
    A0A8C0KF43, A0A8C0QAL3, A0A8I3S2B3
    Related
    ENSCAFP00020014439.1
    Conserved Domains (10) summary
    PLN03209
    Location:973 → 1096
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1130 → 1254
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1822 → 1854
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1378 → 1527
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:1334 → 1364
    EGF; EGF-like domain
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1899 → 2029
    Laminin_G_1; Laminin G domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  13. XM_049110454.1 → XP_048966411.1  agrin isoform X6

  14. XM_049110455.1 → XP_048966412.1  agrin isoform X7

  15. XM_049110463.1 → XP_048966420.1  agrin isoform X17

  16. XM_049110464.1 → XP_048966421.1  agrin isoform X18

  17. XM_049110461.1 → XP_048966418.1  agrin isoform X14

  18. XM_025427595.2 → XP_025283380.1  agrin isoform X15

    UniProtKB/TrEMBL
    A0A8C0KGE0, A0A8I3PEA0, A0A8P0TJW3

RNA

  1. XR_007410857.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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