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TJP2 tight junction protein 2 [ Canis lupus dingo (dingo) ]

Gene ID: 112644752, updated on 10-Oct-2024

Summary

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Gene symbol
TJP2
Gene description
tight junction protein 2
See related
Ensembl:ENSCAFG00020026597
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus dingo (sub-species: dingo)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See TJP2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
30
Annotation release Status Assembly Chr Location
102 current ASM325472v2 (GCF_003254725.2) 1 NC_064243.1 (88258439..88382473, complement)
101 previous assembly UNSW_AlpineDingo_1.0 (GCF_012295265.1) 1 Unlocalized Scaffold NW_023365038.1 (88763915..88888768, complement)

Chromosome 1 - NC_064243.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene DPH3 homolog Neighboring gene uncharacterized LOC112644756 Neighboring gene uncharacterized LOC112644754 Neighboring gene 60S ribosomal protein L7a-like Neighboring gene uncharacterized LOC125752256 Neighboring gene frataxin Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 beta Neighboring gene uncharacterized LOC112644762

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus dingo Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM325472v2

Genomic

  1. NC_064243.1 Reference ASM325472v2

    Range
    88258439..88382473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025423369.3 → XP_025279154.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NNL3
    Conserved Domains (5) summary
    cd12027
    Location:584 → 646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:680 → 859
    GuKc; Guanylate kinase homologues
    smart00228
    Location:284 → 365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:125 → 266
    RSRP; Arginine/Serine-Rich protein 1

  2. XM_049092228.1 → XP_048948185.1  tight junction protein ZO-2 isoform X1

  3. XM_025423367.3 → XP_025279152.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NNL3
    Conserved Domains (5) summary
    cd12027
    Location:584 → 646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:680 → 859
    GuKc; Guanylate kinase homologues
    smart00228
    Location:284 → 365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:125 → 266
    RSRP; Arginine/Serine-Rich protein 1

  4. XM_049092245.1 → XP_048948202.1  tight junction protein ZO-2 isoform X10

  5. XM_049092239.1 → XP_048948196.1  tight junction protein ZO-2 isoform X7

  6. XM_049092220.1 → XP_048948177.1  tight junction protein ZO-2 isoform X4

  7. XM_049092219.1 → XP_048948176.1  tight junction protein ZO-2 isoform X3

  8. XM_049092218.1 → XP_048948175.1  tight junction protein ZO-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LT93

  9. XM_035702316.2 → XP_035558209.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NNL3
    Conserved Domains (5) summary
    cd12027
    Location:584 → 646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:680 → 859
    GuKc; Guanylate kinase homologues
    smart00228
    Location:284 → 365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:125 → 266
    RSRP; Arginine/Serine-Rich protein 1

  10. XM_049092246.1 → XP_048948203.1  tight junction protein ZO-2 isoform X11

  11. XM_035702354.2 → XP_035558247.1  tight junction protein ZO-2 isoform X9

    UniProtKB/TrEMBL
    A0A8C0NF12
    Conserved Domains (5) summary
    cd12027
    Location:607 → 669
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:703 → 882
    GuKc; Guanylate kinase homologues
    smart00228
    Location:307 → 388
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:148 → 289
    RSRP; Arginine/Serine-Rich protein 1

  12. XM_025423365.3 → XP_025279150.1  tight junction protein ZO-2 isoform X6

    UniProtKB/TrEMBL
    A0A8C0NF12
    Conserved Domains (5) summary
    cd12027
    Location:607 → 669
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:703 → 882
    GuKc; Guanylate kinase homologues
    smart00228
    Location:307 → 388
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:148 → 291
    RSRP; Arginine/Serine-Rich protein 1

  13. XM_035702347.2 → XP_035558240.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NNL3
    Conserved Domains (5) summary
    cd12027
    Location:584 → 646
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:680 → 859
    GuKc; Guanylate kinase homologues
    smart00228
    Location:284 → 365
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:125 → 266
    RSRP; Arginine/Serine-Rich protein 1

  14. XM_025423368.3 → XP_025279153.1  tight junction protein ZO-2 isoform X8

    UniProtKB/TrEMBL
    A0A8I3MEQ4, A0A8P0P9M7
    Conserved Domains (5) summary
    cd12027
    Location:611 → 673
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:707 → 886
    GuKc; Guanylate kinase homologues
    smart00228
    Location:311 → 392
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:152 → 295
    RSRP; Arginine/Serine-Rich protein 1

  15. XM_025423364.3 → XP_025279149.1  tight junction protein ZO-2 isoform X5

    UniProtKB/TrEMBL
    A0A8I3MEQ4, A0A8P0P9M7
    Conserved Domains (5) summary
    cd12027
    Location:611 → 673
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:707 → 886
    GuKc; Guanylate kinase homologues
    smart00228
    Location:311 → 392
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam17069
    Location:152 → 295
    RSRP; Arginine/Serine-Rich protein 1
Nucleotide Protein
Heading Accession and Version

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