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CAPN3 calpain 3 [ Theropithecus gelada (gelada) ]

Gene ID: 112627441, updated on 15-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
Ensembl:ENSTGEG00000004361
Gene type
protein coding
RefSeq status
MODEL
Organism
Theropithecus gelada
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Theropithecus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7a
Exon count:
27
Annotation release Status Assembly Chr Location
100 current Tgel_1.0 (GCF_003255815.1) 7a NC_037674.1 (17753999..17812162)

Chromosome 7a - NC_037674.1Genomic Context describing neighboring genes Neighboring gene VPS39 subunit of HOPS complex Neighboring gene transmembrane protein 87A Neighboring gene glucosidase alpha, neutral C Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037674.1 Chromosome 7a Reference Tgel_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Theropithecus gelada Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Tgel_1.0 Primary Assembly

Genomic

  1. NC_037674.1 Reference Tgel_1.0 Primary Assembly

    Range
    17753999..17812162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025389695.1 → XP_025245480.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A8D2EES8, A0A8D2EHJ7
    Related
    ENSTGEP00000005408.1, ENSTGET00000006552.1
    Conserved Domains (3) summary
    pfam00648
    Location:75 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:388 → 531
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:561 → 729
    EFh_PEF_CAPN3; Calcium-activated neutral

  2. XM_025389694.1 → XP_025245479.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A8D2EAA3, A0A8D2EHJ7
    Related
    ENSTGEP00000005406.1, ENSTGET00000006550.1
    Conserved Domains (4) summary
    cd16190
    Location:647 → 815
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 574
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3

  3. XM_025389693.1 → XP_025245478.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A8D2EE84, A0A8D2EHJ7
    Related
    ENSTGEP00000005405.1, ENSTGET00000006547.1
    Conserved Domains (4) summary
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:653 → 821
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III

  4. XM_025389697.1 → XP_025245482.1  calpain-3 isoform X4

    Conserved Domains (3) summary
    pfam01067
    Location:1 → 67
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:71 → 141
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:141 → 309
    EFh_PEF_CAPN3; Calcium-activated neutral

  5. XM_025389699.1 → XP_025245484.1  calpain-3 isoform X5

    Conserved Domains (2) summary
    cd15897
    Location:31 → 60
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:1 → 156
    EFh_PEF; The penta-EF hand (PEF) family

  6. XM_025389698.1 → XP_025245483.1  calpain-3 isoform X5

    Conserved Domains (2) summary
    cd15897
    Location:31 → 60
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:1 → 156
    EFh_PEF; The penta-EF hand (PEF) family
Nucleotide Protein
Heading Accession and Version

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