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TJP2 tight junction protein 2 [ Theropithecus gelada (gelada) ]

Gene ID: 112607823, updated on 15-Mar-2024

Summary

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Gene symbol
TJP2
Gene description
tight junction protein 2
See related
Ensembl:ENSTGEG00000024261
Gene type
protein coding
RefSeq status
MODEL
Organism
Theropithecus gelada
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Theropithecus
Orthologs
human mouse all
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Genomic context

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See TJP2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
27
Annotation release Status Assembly Chr Location
100 current Tgel_1.0 (GCF_003255815.1) 15 NC_037683.1 (82611764..82749207)

Chromosome 15 - NC_037683.1Genomic Context describing neighboring genes Neighboring gene putative uncharacterized protein SPANXA2-OT1 Neighboring gene frataxin Neighboring gene endosomal transmembrane epsin interactor 1 Neighboring gene amyloid beta precursor protein binding family A member 1 Neighboring gene cytochrome c-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037683.1 Chromosome 15 Reference Tgel_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Theropithecus gelada Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Tgel_1.0 Primary Assembly

Genomic

  1. NC_037683.1 Reference Tgel_1.0 Primary Assembly

    Range
    82611764..82749207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025359010.1 → XP_025214795.1  tight junction protein ZO-2 isoform X6

    UniProtKB/TrEMBL
    A0A8D2K7Y9
    Conserved Domains (5) summary
    cd12027
    Location:579 → 641
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:675 → 854
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:274 → 357
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25887
    Location:159 → 275
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  2. XM_025359005.1 → XP_025214790.1  tight junction protein ZO-2 isoform X3

    UniProtKB/TrEMBL
    A0A8D2G650, A0A8D2K7Y9
    Conserved Domains (5) summary
    cd12027
    Location:579 → 641
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:675 → 854
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:274 → 357
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25887
    Location:159 → 275
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  3. XM_025359007.1 → XP_025214792.1  tight junction protein ZO-2 isoform X3

    UniProtKB/TrEMBL
    A0A8D2G650, A0A8D2K7Y9
    Related
    ENSTGEP00000030280.1, ENSTGET00000036014.1
    Conserved Domains (5) summary
    cd12027
    Location:579 → 641
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:675 → 854
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:274 → 357
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25887
    Location:159 → 275
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  4. XM_025359004.1 → XP_025214789.1  tight junction protein ZO-2 isoform X2

    UniProtKB/TrEMBL
    A0A8D2G5X9, A0A8D2K7Y9
    Related
    ENSTGEP00000030290.1, ENSTGET00000036025.1
    Conserved Domains (5) summary
    cd12027
    Location:602 → 664
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:698 → 877
    GuKc; Guanylate kinase homologues
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:297 → 380
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25887
    Location:182 → 298
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  5. XM_025359009.1 → XP_025214794.1  tight junction protein ZO-2 isoform X5

    UniProtKB/TrEMBL
    A0A8D2G867, A0A8D2K7Y9
    Related
    ENSTGEP00000030303.1, ENSTGET00000036041.1
    Conserved Domains (5) summary
    cd12027
    Location:602 → 664
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:698 → 877
    GuKc; Guanylate kinase homologues
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:297 → 380
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25887
    Location:182 → 298
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  6. XM_025359008.1 → XP_025214793.1  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A8D2K7Y9
    Conserved Domains (5) summary
    cd12027
    Location:606 → 668
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:702 → 881
    GuKc; Guanylate kinase homologues
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:301 → 384
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25887
    Location:148 → 230
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  7. XM_025359003.1 → XP_025214788.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A8D2G5I0, A0A8D2K7Y9
    Related
    ENSTGEP00000030310.1, ENSTGET00000036048.1
    Conserved Domains (5) summary
    cd12027
    Location:633 → 695
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:729 → 908
    GuKc; Guanylate kinase homologues
    cd00992
    Location:63 → 148
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:328 → 411
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl25887
    Location:175 → 257
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
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