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Sle2 systemic lupus erythmatosus susceptibility 2 [ Mus musculus (house mouse) ]

Gene ID: 112366, updated on 17-Aug-2024

Summary

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Official Symbol
Sle2provided by MGI
Official Full Name
systemic lupus erythmatosus susceptibility 2provided by MGI
Primary source
MGI:MGI:105963
Gene type
unknown
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus

Genomic context

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Location:
4 39.4 cM

Bibliography

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Related articles in PubMed

  1. Autoimmune-mediated glucose intolerance in a mouse model of systemic lupus erythematosus. Gabriel CL, et al. Am J Physiol Endocrinol Metab, 2012 Dec 1. PMID 23032686, Free PMC Article
  2. A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells. Xu Z, et al. J Immunol, 2011 Apr 1. PMID 21335485, Free PMC Article
  3. Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes. Zeumer L, et al. Genes Immun, 2011 Apr. PMID 21270826, Free PMC Article
  4. Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells. Liu Y, et al. J Immunol, 2007 Jul 15. PMID 17617627
  5. The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice. Xu Z, et al. Arthritis Rheum, 2011 Mar. PMID 21360506, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results show that Sle2c1 contributes to lupus pathogenesis by affecting T cell differentiation in combination with other susceptibility loci, such as lpr.
    Title: The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice.
  2. Mice of the B6.NZMSle1/Sle2/Sle3 (Sle1,2,3) lupus-prone strain also express an interferon (IFN) signature compared with non-autoimmune C57BL/6 mice.
    Title: Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.
  3. The -74C-to-T single nucleotide polymorphism (SNP) plays a functional role in decreasing p18/Inc4c expression in association with the Sle2c1 lupus susceptibility locus.
    Title: Genetic variation at a Yin-Yang 1 response site regulates the transcription of cyclin-dependent kinase inhibitor p18INK4C transcript in lupus-prone mice.
  4. study showed that at least two Sle2 genes are involved in the activation of anti-DNA B cells.
    Title: Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes.
  5. The Sle2c2 locus of New Zealand Black mice contains a potent lupus susceptibility gene which suppresses T cell-induced autoimmune responses through myeloid-derived suppressor cells.
    Title: A New Zealand Black-derived locus suppresses chronic graft-versus-host disease and autoantibody production through nonlymphoid bone marrow-derived cells.
  6. Results show that the systemic lupus erythmatosus susceptibility 2 locus regulates the size of the B-1a cell compartment at multiple developmental checkpoints.
    Title: Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2.
  7. The Sle2 locus contains several loci affecting B cell development, with only the two New Zealand white (NZW) strain-derived loci having the least effect of B-1a cell accumulation significantly contributing to lupus pathogenesis.
    Title: Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.
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Phenotypes

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Associated conditions

Description Tests
systemic lupus erythmatosus susceptibility 2
GeneReviews: Not available

General gene information

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Markers

Property

  • phenotype only

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