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LOC112296187 Sharpr-MPRA regulatory region 5052 [ Homo sapiens (human) ]

Gene ID: 112296187, updated on 10-Oct-2023

Summary

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Gene symbol
LOC112296187
Gene description
Sharpr-MPRA regulatory region 5052
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 7:EnhWF, candidate poised/weak enhancer; flanking open chromatin of candidate enhancers) and K562 erythroleukemia cells (group: K562 Activating DNase matched - State 8:EnhW, candidate weak enhancer and open chromatin). [provided by RefSeq, Apr 2018]
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Genomic context

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See LOC112296187 in Genome Data Viewer
Location:
16p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (12426252..12426546)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (12463212..12463506)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (12520109..12520403)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene sorting nexin 29 Neighboring gene small nucleolar RNA ACA64 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12405377-12405883 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12404869-12405376 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12407183-12407683 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12408231-12408918 Neighboring gene Sharpr-MPRA regulatory region 2664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12410661-12411592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12426104-12426604 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:12435179-12436378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10468 Neighboring gene uncharacterized LOC101927227 Neighboring gene uncharacterized LOC105371087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12479845-12480345 Neighboring gene Sharpr-MPRA regulatory region 12750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12529425-12530112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12530113-12530799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12532613-12533114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12561965-12562466 Neighboring gene uncharacterized LOC124903644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:12612096-12612755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12616566-12617066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12620609-12621109 Neighboring gene uncharacterized LOC105371085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12685995-12686514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056772.1 

    Range
    101..395
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    12426252..12426546
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    12463212..12463506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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