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LOC112272620 H3K4me1 hESC enhancer GRCh37_chr15:77892119-77892619 [ Homo sapiens (human) ]

Gene ID: 112272620, updated on 10-Oct-2023

Summary

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Gene symbol
LOC112272620
Gene description
H3K4me1 hESC enhancer GRCh37_chr15:77892119-77892619
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells, where it is marked by the H3K4me1 histone modification. A subregion was also validated as an enhancer by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 10:DNaseD, primarily Duke DNase, candidate regulatory elements in more likely repressive locations) and K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 5:Enh, candidate strong enhancer, open chromatin). [provided by RefSeq, Jan 2023]
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Genomic context

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See LOC112272620 in Genome Data Viewer
Location:
15q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (77599777..77600277)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (75460483..75460983)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (77892229..77892523)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene pseudopodium enriched atypical kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9896 Neighboring gene high mobility group 20A Neighboring gene Sharpr-MPRA regulatory region 2172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77787952-77788752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77789555-77790354 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77799871-77800847 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77801824-77802800 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77802801-77803775 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77817641-77818484 Neighboring gene uncharacterized LOC101929457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77819329-77820172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77821015-77821858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77822701-77823544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77821859-77822700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:77826181-77826682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:77826683-77827182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77833845-77834524 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:77836028-77836242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77844823-77845466 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77846672-77847265 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77847266-77847858 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77849047-77849640 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77849641-77850232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77857721-77858585 Neighboring gene uncharacterized LOC105370906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77863406-77863906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77863907-77864407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77866115-77866615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77874268-77874768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77876983-77877794 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:77893796-77893952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77897574-77898293 Neighboring gene Sharpr-MPRA regulatory region 5143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77903637-77904464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77906671-77907170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77908397-77909223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77913981-77914496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77914497-77915012 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77916045-77916560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77922113-77922678 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:77926073-77926636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77937918-77938418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77942484-77942984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:77952267-77953188 Neighboring gene LINGO1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77959162-77959662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:77959663-77960163 Neighboring gene leucine rich repeat and Ig domain containing 1 Neighboring gene LINGO1 antisense RNA 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • Sharpr-MPRA regulatory region 8640

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056754.2 

    Range
    101..601
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    77599777..77600277
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    75460483..75460983
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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