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LOC112136094 Sharpr-MPRA regulatory region 9656 [ Homo sapiens (human) ]

Gene ID: 112136094, updated on 10-Oct-2023

Summary

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Gene symbol
LOC112136094
Gene description
Sharpr-MPRA regulatory region 9656
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 17:Gen3', transcription 3' end of genes, highly expressed; more exonic). [provided by RefSeq, Mar 2018]
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Genomic context

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See LOC112136094 in Genome Data Viewer
Location:
11p
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (9139022..9139316)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (9223793..9224087)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9160569..9160863)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9116861-9117362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9117363-9117862 Neighboring gene keratin 8 pseudogene 41 Neighboring gene uncharacterized LOC105376542 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:9142475-9143138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4401 Neighboring gene DENN domain containing 5A Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:9190693-9191892 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:9250779-9251379 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:9251982-9252582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:9273812-9274511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4405 Neighboring gene MPRA-validated peak1192 silencer Neighboring gene tRNA-Leu (CAA) 5-1 Neighboring gene transmembrane protein 41B Neighboring gene proline rich 13 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056533.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    9139022..9139316
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    9223793..9224087
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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