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LOC111875819 Sharpr-MPRA regulatory region 15000 [ Homo sapiens (human) ]

Gene ID: 111875819, updated on 10-Oct-2023

Summary

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Gene symbol
LOC111875819
Gene description
Sharpr-MPRA regulatory region 15000
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in both HepG2 liver carcinoma cells (group: HepG2 Activating DNase unmatched - State 12:CtcfO, distal CTCF/candidate insulator with open chromatin) and K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 12:CtcfO). [provided by RefSeq, Feb 2018]
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Genomic context

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Location:
10q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103598852..103599146)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (104486187..104486481)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105358609..105358903)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NEURL1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105253807-105254356 Neighboring gene Sharpr-MPRA regulatory region 14515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3966 Neighboring gene neuralized E3 ubiquitin protein ligase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105287340-105287840 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:105287841-105288341 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105323539-105324519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105329056-105329556 Neighboring gene uncharacterized LOC124902496 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2785 Neighboring gene Sharpr-MPRA regulatory region 3797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105367121-105367978 Neighboring gene SH3 and PX domains 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105380856-105381356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105395283-105395862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105396445-105397024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105399548-105400343 Neighboring gene Sharpr-MPRA regulatory region 2777 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105417537-105418038 Neighboring gene uncharacterized LOC124902495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105441739-105442519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105451952-105452918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105455468-105456214 Neighboring gene NFE2L2 motif-containing MPRA enhancer 292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105467435-105468414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105468415-105469393 Neighboring gene NANOG hESC enhancer GRCh37_chr10:105482339-105482840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105491951-105492499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105492500-105493047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105505582-105506103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105506520-105507020 Neighboring gene SH3PXD2A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105507021-105507521

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056295.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    103598852..103599146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    104486187..104486481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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