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INMT indolethylamine N-methyltransferase [ Homo sapiens (human) ]

Gene ID: 11185, updated on 5-Mar-2024

Summary

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Official Symbol
INMTprovided by HGNC
Official Full Name
indolethylamine N-methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:6069
See related
Ensembl:ENSG00000241644 MIM:604854; AllianceGenome:HGNC:6069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEMT
Summary
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]
Expression
Broad expression in lung (RPKM 67.4), adrenal (RPKM 18.7) and 14 other tissues See more
Orthologs
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Genomic context

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See INMT in Genome Data Viewer
Location:
7p14.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (30752135..30757602)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (30889798..30895267)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (30791751..30797218)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone receptor 2 Neighboring gene uncharacterized LOC124901608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30727952-30728462 Neighboring gene uncharacterized LOC105375220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30747055-30747555 Neighboring gene uncharacterized LOC105375219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30766987-30767488 Neighboring gene INMT-MINDY4 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18072 Neighboring gene Sharpr-MPRA regulatory region 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18073 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:30823626-30824126 Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25819 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:30893171-30894073 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30901315-30901474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30923659-30924560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30941843-30942646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30942647-30943449 Neighboring gene oxysterol binding protein like 9 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30946833-30947332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:30948457-30948956 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:30961348-30961528 Neighboring gene aquaporin 1 (Colton blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer. Zhong S, et al. J Exp Clin Cancer Res, 2021 Sep 29. PMID 34587977, Free PMC Article
  2. Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants. Torres B, et al. PLoS One, 2019. PMID 31310642, Free PMC Article
  3. Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene. Kuehnelt D, et al. Am J Clin Nutr, 2015 Dec. PMID 26537946
  4. Potential Association of INMT Nonsynonymous Variant (His46Pro) with Hirschsprung's Disease. Kim JY, et al. Neonatology, 2015. PMID 26183064
  5. Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. Kopantzev EP, et al. Lung Cancer, 2008 Oct. PMID 18394749

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion.
    Title: Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion.
  2. Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer.
    Title: Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer.
  3. analysis of 254C and 254F variants of hINMT reveals differences in methylation of tryptamine, dimethylsulfide and dimethylselenide
    Title: Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants.
  4. study suggests that rs77743549 of INMT may be associated with the risk for Hirschsprung's disease
    Title: Potential Association of INMT Nonsynonymous Variant (His46Pro) with Hirschsprung's Disease.
  5. genome-wide association studies in populations in Argentina/Bangladeshi: Three SNPs in INMT (rs6970396, rs1061644, rs4270015) are associated with production of trimethylselenonium (TMSe); urinary Se excretion is up-regulated in TMSe-producing women.
    Title: Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene.
  6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough INMT-MINDY4

Readthrough gene: INMT-MINDY4, Included gene: MINDY4

Homology

Clone Names

  • MGC125940, MGC125941

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables amine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioether S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
indolethylamine N-methyltransferase
Names
amine N-methyltransferase
aromatic alkylamine N-methyltransferase
arylamine N-methyltransferase
indolamine N-methyltransferase
nicotine N-methyltransferase
thioether S-methyltransferase
NP_001186148.1
NP_006765.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047126.1 RefSeqGene

    Range
    5001..10468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199219.2 → NP_001186148.1  indolethylamine N-methyltransferase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AC006022, AK313832, BC033813, DA920005
    Consensus CDS
    CCDS56479.1
    UniProtKB/TrEMBL
    A0A090N7V3, Q3MIB5
    Related
    ENSP00000386961.1, ENST00000409539.1
    Conserved Domains (1) summary
    pfam01234
    Location:4 → 258
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

  2. NM_006774.5 → NP_006765.4  indolethylamine N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_006765.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006022, AF128846, BC033813
    Consensus CDS
    CCDS5430.1
    UniProtKB/Swiss-Prot
    B8ZZ69, O95050, Q3KP49, Q9P1Y2, Q9UBY4, Q9UHQ0
    UniProtKB/TrEMBL
    A0A090N7V3, Q3MIB5
    Related
    ENSP00000013222.5, ENST00000013222.5
    Conserved Domains (1) summary
    pfam01234
    Location:4 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    30752135..30757602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    30889798..30895267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95050.3 GenPept UniProtKB/Swiss-Prot:O95050

Gene LinkOut

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