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LOC111832671 albumin (ALB) 5' regulatory region [ Homo sapiens (human) ]

Gene ID: 111832671, updated on 15-Mar-2024

Summary

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Gene symbol
LOC111832671
Gene description
albumin (ALB) 5' regulatory region
Gene type
biological region
Feature type(s)
protein_bind
regulatory: TATA_box, enhancer, promoter
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the promoter and associated upstream enhancers of the albumin (ALB) gene, which is relevant for COVID-19 prognosis. Activity of this region is stimulated by binding by HNF1 homeobox A and CCAAT/enhancer-binding protein, and is negatively regulated by tumor protein p53. An enhancer in this region may also regulate activity of the alpha fetoprotein promoter located approximately 30 kb downstream. [provided by RefSeq, Jun 2021]
Annotation information
Note: This locus has been reviewed for its involvement in coronavirus biology, and is involved in host gene regulation.
Orthologs
mouse all
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Genomic context

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Location:
4q13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (73397685..73404342)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (76741387..76748044)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74263402..74270059)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 17 Neighboring gene uncharacterized LOC124900713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:74121667-74122167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15476 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:74124568-74125164 Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene ANKRD17 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:74191462-74192661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:74205305-74205804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:74204803-74205304 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:74209023-74209524 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:74235125-74235832 Neighboring gene alpha fetoprotein (AFP) 5' regulatory region Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:74315627-74316826 Neighboring gene albumin Neighboring gene alpha fetoprotein Neighboring gene NANOG hESC enhancer GRCh37_chr4:74360223-74360724 Neighboring gene afamin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction of a general albumin promoter reporter system for real-time monitoring of the differentiation status of functional hepatocytes from stem cells in mouse, rat and human. Tang J, et al. Biomed Rep, 2017 Jun. PMID 28584633, Free PMC Article
  2. p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis. Kubicka S, et al. J Biol Chem, 1999 Nov 5. PMID 10542249
  3. Activation of albumin and other liver-specific gene expression in fibroblast-pancreatic cell hybrids: different roles of transcription factors. Wu KJ. Exp Cell Res, 1993 Sep. PMID 8102976
  4. Binding of a liver-specific factor to the human albumin gene promoter and enhancer. Frain M, et al. Mol Cell Biol, 1990 Mar. PMID 2304474, Free PMC Article
  5. Evaluation of relative promoter strength in primary hepatocytes using optimized lipofection. Ponder KP, et al. Hum Gene Ther, 1991 Spring. PMID 1863638

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Homology

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_056261.1 

    Range
    101..6758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    73397685..73404342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    76741387..76748044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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