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PLCH2 phospholipase C eta 2 [ Equus caballus (horse) ]

Gene ID: 111770195, updated on 17-Aug-2024

Summary

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Official Symbol
PLCH2provided by VGNC
Official Full Name
phospholipase C eta 2provided by VGNC
Primary source
VGNC:VGNC:111060
See related
Ensembl:ENSECAG00000031378
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See PLCH2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 2 NC_009145.3 (47648532..47734676, complement)

Chromosome 2 - NC_009145.3Genomic Context describing neighboring genes Neighboring gene hes family bHLH transcription factor 5 Neighboring gene pantothenate kinase 4 (inactive) Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene retention in endoplasmic reticulum sorting receptor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009145.3 Chromosome 2 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009145.3 Reference EquCab3.0 Primary Assembly

    Range
    47648532..47734676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023627475.1 → XP_023483243.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    Conserved Domains (6) summary
    cd00275
    Location:750 → 875
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:315 → 720
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:34 → 140
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:909 → 1401
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:158 → 303
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  2. XM_023627461.1 → XP_023483229.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    Conserved Domains (6) summary
    cd00275
    Location:750 → 875
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:315 → 720
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:34 → 140
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:909 → 1401
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:158 → 303
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  3. XM_023627470.1 → XP_023483238.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    Conserved Domains (6) summary
    cd00275
    Location:750 → 875
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:315 → 720
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:34 → 140
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:909 → 1401
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:158 → 303
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  4. XM_023627463.1 → XP_023483231.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    Conserved Domains (6) summary
    cd00275
    Location:750 → 875
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:315 → 720
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:34 → 140
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:909 → 1401
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:158 → 303
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  5. XM_023627467.1 → XP_023483235.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    Conserved Domains (6) summary
    cd00275
    Location:750 → 875
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:315 → 720
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:34 → 140
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:909 → 1401
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:158 → 303
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  6. XM_023627452.1 → XP_023483220.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

    Conserved Domains (6) summary
    cd00275
    Location:762 → 887
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:327 → 732
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:46 → 152
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:170 → 199
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:921 → 1413
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:170 → 315
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  7. XM_023627453.1 → XP_023483221.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

    Conserved Domains (5) summary
    cd00275
    Location:757 → 882
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:322 → 727
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:46 → 152
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd16221
    Location:170 → 310
    EFh_PI-PLCeta2; EF-hand motif found in phosphoinositide phospholipase C eta 2 (PI-PLC-eta2)
    cl26464
    Location:916 → 1408
    Atrophin-1; Atrophin-1 family

  8. XM_023627487.1 → XP_023483255.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

    Conserved Domains (6) summary
    cd00275
    Location:734 → 859
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:299 → 704
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:18 → 124
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:142 → 171
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:893 → 1385
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:142 → 287
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  9. XM_023627485.1 → XP_023483253.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

    Conserved Domains (6) summary
    cd00275
    Location:738 → 863
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:303 → 708
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:22 → 128
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:146 → 175
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:897 → 1389
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:146 → 291
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  10. XM_023627500.1 → XP_023483268.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2L488
    Related
    ENSECAP00000032848.2, ENSECAT00000063963.2
    Conserved Domains (6) summary
    cd00275
    Location:762 → 887
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:327 → 732
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:46 → 152
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:170 → 199
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:921 → 1119
    Atrophin-1; Atrophin-1 family
    cl28895
    Location:170 → 315
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

RNA

  1. XR_002803322.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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