U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ifna interferon alpha [ Mus musculus (house mouse) ]

Gene ID: 111654, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Ifnaprovided by MGI
Official Full Name
interferon alphaprovided by MGI
Primary source
MGI:MGI:107670
Gene type
other
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifa; Ifa8
Annotation information
not in current annotation release
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 C3-C6; 4

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The B6.CE-Lyb-2c:Mup-1a mouse strain contains the interferon-alpha genes from C57BL/6. Gollahon KA, et al. Immunogenetics, 1992. PMID 1345906
  2. Maturation inside and outside bone marrow dendritic cells (BMDCs) modulated by interferon-α (IFN-α). Song Q, et al. Int Immunopharmacol, 2013 Nov. PMID 24095953
  3. Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity. Johnson MJ, et al. J Immunol, 2012 Jun 15. PMID 22586038, Free PMC Article
  4. IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms. Akeno N, et al. J Immunol, 2011 Apr 15. PMID 21402899, Free PMC Article
  5. Interferon-α increases monocyte migration via platelet-monocyte interaction in murine intestinal microvessels. Higashiyama M, et al. Clin Exp Immunol, 2010 Oct. PMID 20659125, Free PMC Article

See all (212) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interleukin-6 and interferon-alpha differentially regulate microglia function.
    Title: Interleukin-6 and interferon-alpha differentially regulate microglia function.
  2. Interferon-Alpha Induces Psoriatic Inflammation in Mice by Phosphorylating FOXO3.
    Title: Interferon-Alpha Induces Psoriatic Inflammation in Mice by Phosphorylating FOXO3.
  3. Interferon-alpha stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.
    Title: Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.
  4. Hemolysis-driven IFNalpha production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease.
    Title: Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease.
  5. Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-alpha.
    Title: Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α.
  6. Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.
    Title: Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection.
  7. The association of interferon-alpha with development of collateral circulation after artery occlusion.
    Title: The association of interferon-alpha with development of collateral circulation after artery occlusion.
  8. Microglial responses to peripheral type 1 interferon.
    Title: Microglial responses to peripheral type 1 interferon.
  9. Type I interferon receptor-independent interferon-alpha induction upon infection with a variety of negative-strand RNA viruses.
    Title: Type I interferon receptor-independent interferon-α induction upon infection with a variety of negative-strand RNA viruses.
  10. Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN-alpha.
    Title: Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN-α.
Submit: New GeneRIF Correction See all GeneRIFs (101)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Other Names

  • interferon alpha gene family, leukocyte

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within humoral immune response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials