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Tcra-V14 T cell receptor alpha, variable 14 [ Mus musculus (house mouse) ]

Gene ID: 111622, updated on 17-Aug-2024

Summary

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Official Symbol
Tcra-V14provided by MGI
Official Full Name
T cell receptor alpha, variable 14provided by MGI
Primary source
MGI:MGI:98561
See related
AllianceGenome:MGI:98561
Gene type
other
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Valpha14
Summary
Is expressed in thymus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
not in current annotation release
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Genomic context

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Location:
chromosome: 14

Bibliography

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Related articles in PubMed

  1. NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology. Vahl JC, et al. PLoS Biol, 2013. PMID 23853545, Free PMC Article
  2. Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Dose M, et al. Proc Natl Acad Sci U S A, 2009 May 26. PMID 19423665, Free PMC Article
  3. Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells. Li X, et al. J Immunol, 2009 Oct 1. PMID 19734232, Free PMC Article
  4. Genomic organization of the mouse T cell receptor V alpha family. Jouvin-Marche E, et al. EMBO J, 1990 Jul. PMID 2357962, Free PMC Article
  5. Heterogeneity of NK1.1+ T cells in the bone marrow: divergence from the thymus. Zeng D, et al. J Immunol, 1999 Nov 15. PMID 10553057

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. naive T cells are activated upon replacement of their endogenous T cell receptor (TCR) repertoire with Valpha14i-restricted TCRs.
    Title: NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology.
  2. Data indicate that Valpha14 invariant natural killer T (Valpha14i NKT) cells from Th-POK-mutant helper deficient (hd/hd) mice have increased transcripts of genes normally expressed by Th17 and NKT17 cells.
    Title: The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells.
  3. Affinity to invariant T cell receptor rather than to CD1d molecule appears to govern in shaping the strength of the biological activity of C-glycoside analogues against invariant natural killer (NK)T cells from human compared to that of mouse.
    Title: Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells.
  4. c-Myc mediates an intrathymic proliferation wave immediately after agonist selection of iNKT cells
    Title: Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc.
Submit: New GeneRIF Correction

General gene information

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Markers

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