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LOC111501777 NFE2L2 motif-containing MPRA enhancer 298 [ Homo sapiens (human) ]

Gene ID: 111501777, updated on 17-Jun-2024

Summary

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Gene symbol
LOC111501777
Gene description
NFE2L2 motif-containing MPRA enhancer 298
Gene type
biological region
Feature type(s)
regulatory: enhancer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by high-throughput massively parallel reporter assays (MPRAs) in K562 erythroleukemia cells. This enhancer contains a conserved motif for the NFE2L2 activator. Mutation of this motif results in reduced enhancer activity. [provided by RefSeq, Nov 2017]
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Genomic context

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See LOC111501777 in Genome Data Viewer
Location:
9q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (134344347..134344491)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (146559525..146559669)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (137236193..137236337)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137159240-137159872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137165779-137166534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137186973-137187694 Neighboring gene long intergenic non-protein coding RNA 2247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137210088-137210946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137210947-137211805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137219587-137220516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137220517-137221446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137225116-137225782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137225783-137226449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137237611-137238182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137241753-137242539 Neighboring gene retinoid X receptor alpha Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137242540-137243325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137243326-137244112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137244113-137244897 Neighboring gene RXRA intron CAGE-defined high expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137269547-137270338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137270339-137271130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137271131-137271922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20481 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137276487-137276988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29281 Neighboring gene Sharpr-MPRA regulatory region 14205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29282 Neighboring gene microRNA 4669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137288759-137289667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137292875-137293376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137293377-137293876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137298902-137299714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137299715-137300527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137300528-137301339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137312909-137313409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137325655-137326156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137326157-137326656 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137328808-137329376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137335184-137335762 Neighboring gene uncharacterized LOC105376311 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:137338907-137339314 Neighboring gene Sharpr-MPRA regulatory region 11314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137346195-137347030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137347374-137348311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:137348312-137349248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:137353764-137354264 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:137367387-137367888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay. Kheradpour P, et al. Genome Res, 2013 May. PMID 23512712, Free PMC Article
  2. Mapping and analysis of chromatin state dynamics in nine human cell types. Ernst J, et al. Nature, 2011 May 5. PMID 21441907, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • NFE2L2 activator MPRA enhancer 298
  • massively parallel reporter assay enhancer 298

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055942.1 

    Range
    101..245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    134344347..134344491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    146559525..146559669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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