U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC111365156 NFE2L2 motif-containing MPRA enhancer 24 [ Homo sapiens (human) ]

Gene ID: 111365156, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC111365156
Gene description
NFE2L2 motif-containing MPRA enhancer 24
Gene type
biological region
Feature type(s)
regulatory: enhancer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was predicted to be a cell type-specific enhancer based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by high-throughput massively parallel reporter assays (MPRAs) in both liver carcinoma HepG2 cells and erythroleukemia K562 cells. This enhancer contains a conserved motif for the NFE2L2 activator. Mutation of this motif results in reduced enhancer activity. [provided by RefSeq, Nov 2017]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (79971060..79971204)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (86031766..86031910)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (80004957..80005101)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371356 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:79804516-79804714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11161 Neighboring gene MAF transcriptional regulator RNA Neighboring gene long intergenic non-protein coding RNA 1229 Neighboring gene long intergenic non-protein coding RNA 1228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11164 Neighboring gene HNF4 motif-containing MPRA enhancer 204/205 Neighboring gene Sharpr-MPRA regulatory region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11165 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:80006081-80006287 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:80060683-80061882 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:80078510-80079709 Neighboring gene uncharacterized LOC105371357 Neighboring gene uncharacterized LOC105371358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7739 Neighboring gene DYNLRB2 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:80231288-80232487 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:80255087-80255329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7740 Neighboring gene Sharpr-MPRA regulatory region 10203 Neighboring gene Sharpr-MPRA regulatory region 10573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:80351553-80352053 Neighboring gene VISTA enhancer hs4 Neighboring gene HNF1 motif-containing MPRA enhancer 101 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:80499762-80500344 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:80500345-80500926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11167 Neighboring gene dynein light chain roadblock-type 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay. Kheradpour P, et al. Genome Res, 2013 May. PMID 23512712, Free PMC Article
  2. Mapping and analysis of chromatin state dynamics in nine human cell types. Ernst J, et al. Nature, 2011 May 5. PMID 21441907, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • NFE2L2 activator MPRA enhancer 24
  • massively parallel reporter assay enhancer 24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055712.1 

    Range
    101..245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    79971060..79971204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    86031766..86031910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases