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CAPN11 calpain 11 [ Homo sapiens (human) ]

Gene ID: 11131, updated on 5-Mar-2024

Summary

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Official Symbol
CAPN11provided by HGNC
Official Full Name
calpain 11provided by HGNC
Primary source
HGNC:HGNC:1478
See related
Ensembl:ENSG00000137225 MIM:604822; AllianceGenome:HGNC:1478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
calpain11
Summary
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
Expression
Restricted expression toward testis (RPKM 18.7) See more
Orthologs
mouse all
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Genomic context

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See CAPN11 in Genome Data Viewer
Location:
6p21.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (44158820..44184401)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43992275..44018561)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44126557..44152138)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91835 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17254 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:44098898-44099057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44100902-44101867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44101868-44102832 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91847 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91852 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91874 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91884 Neighboring gene uncharacterized LOC107986599 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44134475-44135357 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:44137200-44138399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44144390-44145092 Neighboring gene uncharacterized LOC105375072 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene transmembrane protein 63B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44168290-44169290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44169291-44170290 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44170291-44171291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44171292-44172291 Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene myomixer, myoblast fusion factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6. Dear TN, et al. Genomics, 1999 Jul 15. PMID 10409436
  2. Calpain: new perspectives in molecular diversity and physiological-pathological involvement. Saido TC, et al. FASEB J, 1994 Aug. PMID 8070630
  3. The calpains. Melloni E, et al. Trends Neurosci, 1989 Nov. PMID 2479145
  4. Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa. Rojas FJ, et al. Mol Hum Reprod, 1999 Jun. PMID 10340998
  5. Calpain 11 is unique to mouse spermatogenic cells. Ben-Aharon I, et al. Mol Reprod Dev, 2006 Jun. PMID 16541461, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calpain-11
Names
CANP 11
calcium-activated neutral proteinase 11
NP_008989.2
XP_006715047.1
XP_006715048.1
XP_006715050.1
XP_011512576.1
XP_011512577.1
XP_054210100.1
XP_054210101.1
XP_054210102.1
XP_054210103.1
XP_054210104.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007058.4 → NP_008989.2  calpain-11

    See identical proteins and their annotated locations for NP_008989.2

    Status: REVIEWED

    Source sequence(s)
    AJ242832, BC033733, DB052011
    Consensus CDS
    CCDS47436.1
    UniProtKB/Swiss-Prot
    B2RA64, Q5T3G1, Q8N4R5, Q9UMQ6
    Related
    ENSP00000381758.1, ENST00000398776.2
    Conserved Domains (3) summary
    pfam00648
    Location:80 → 376
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:390 → 544
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:615 → 665
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    44158820..44184401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514274.2 → XP_011512576.1  calpain-11 isoform X3

    Conserved Domains (3) summary
    pfam00648
    Location:85 → 381
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:395 → 549
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:620 → 670
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_011514275.1 → XP_011512577.1  calpain-11 isoform X4

    Conserved Domains (3) summary
    pfam00648
    Location:84 → 380
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:394 → 548
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:619 → 669
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_006714984.2 → XP_006715047.1  calpain-11 isoform X1

    Conserved Domains (3) summary
    pfam00648
    Location:81 → 377
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:391 → 545
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:616 → 666
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_006714985.2 → XP_006715048.1  calpain-11 isoform X2

    Conserved Domains (3) summary
    pfam00648
    Location:81 → 377
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:391 → 545
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:616 → 666
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_006714987.2 → XP_006715050.1  calpain-11 isoform X5

    Conserved Domains (2) summary
    pfam00648
    Location:81 → 377
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:391 → 545
    Calpain_III; Calpain large subunit, domain III

RNA

  1. XR_001743136.2 RNA Sequence

  2. XR_001743135.2 RNA Sequence

  3. XR_926042.2 RNA Sequence

  4. XR_001743134.2 RNA Sequence

  5. XR_926043.2 RNA Sequence

  6. XR_926044.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43992275..44018561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354127.1 → XP_054210102.1  calpain-11 isoform X3

  2. XM_054354128.1 → XP_054210103.1  calpain-11 isoform X4

  3. XM_054354125.1 → XP_054210100.1  calpain-11 isoform X1

  4. XM_054354126.1 → XP_054210101.1  calpain-11 isoform X2

  5. XM_054354129.1 → XP_054210104.1  calpain-11 isoform X5

RNA

  1. XR_008487247.1 RNA Sequence

  2. XR_008487246.1 RNA Sequence

  3. XR_008487244.1 RNA Sequence

  4. XR_008487245.1 RNA Sequence

  5. XR_008487248.1 RNA Sequence

  6. XR_008487249.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UMQ6.2 GenPept UniProtKB/Swiss-Prot:Q9UMQ6

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