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ZWINT ZW10 interacting kinetochore protein [ Homo sapiens (human) ]

Gene ID: 11130, updated on 5-Mar-2024

Summary

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Official Symbol
ZWINTprovided by HGNC
Official Full Name
ZW10 interacting kinetochore proteinprovided by HGNC
Primary source
HGNC:HGNC:13195
See related
Ensembl:ENSG00000122952 MIM:609177; AllianceGenome:HGNC:13195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIP30; ZWINT1; KNTC2AP; HZwint-1
Summary
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 17.2), testis (RPKM 16.4) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
10q21.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (56357227..56361273, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (57207567..57211612, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (58116988..58121034, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 21 Neighboring gene zinc finger MYM-type containing 4 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:57507392-57507557 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:57581693-57582274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:57582275-57582855 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:57659053-57659628 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:57659629-57660203 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:57738855-57739607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2373 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:58118905-58120104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:58120730-58121469 Neighboring gene uncharacterized LOC124902546 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:58297350-58298549 Neighboring gene small nucleolar RNA SNORD2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion. Yang L, et al. Oncol Rep, 2020 Jun. PMID 32323832, Free PMC Article
  2. ZWINT is the next potential target for lung cancer therapy. Peng F, et al. J Cancer Res Clin Oncol, 2019 Mar. PMID 30643969
  3. Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery. Yang XY, et al. Technol Cancer Res Treat, 2018 Jan 1. PMID 30198401, Free PMC Article
  4. Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis. Woo Seo D, et al. Sci Rep, 2015 Oct 21. PMID 26486467, Free PMC Article
  5. Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation. He Y, et al. Cell Biochem Funct, 2020 Jun. PMID 31945194

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
    Title: ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
  2. Genome-wide association analysis of cognitive function in Danish long-lived individuals.
    Title: Genome-wide association analysis of cognitive function in Danish long-lived individuals.
  3. Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
    Title: Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
  4. ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
    Title: ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
  5. upregulated in prostate cancer tissues
    Title: Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.
  6. results suggested ZWINT as a potential gene associated with lung cancer cell proliferation
    Title: ZWINT is the next potential target for lung cancer therapy.
  7. ZW10 interactor was frequently decreased in hepatocellular carcinoma.
    Title: Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery.
  8. Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis.
    Title: Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.
  9. the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation
    Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
  10. These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase
    Title: Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of localization in cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of localization in cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in homologous chromosome orientation in meiotic metaphase I ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of meiosis I spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Knl1/Spc105 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
ZW10 interactor
Names
SNAP25 interacting protein of 30 kDa
ZW10 interactor, kinetochore protein
human ZW10 interacting protein-1
zwint-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033939.1 RefSeqGene

    Range
    5015..9047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005413.1 → NP_001005413.1  ZW10 interactor isoform b

    See identical proteins and their annotated locations for NP_001005413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC016357, BC020979, BG615304, BM724168
    Consensus CDS
    CCDS31205.1
    UniProtKB/TrEMBL
    B4DP12
    Related
    ENSP00000354921.6, ENST00000361148.6
    Conserved Domains (1) summary
    pfam15556
    Location:29 → 230
    Zwint; ZW10 interactor

  2. NM_007057.4 → NP_008988.2  ZW10 interactor isoform a

    See identical proteins and their annotated locations for NP_008988.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and differs in the 3' UTR compared to variant 2. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AC010996, BC000411, BC016357, BC020979, BG615304
    Consensus CDS
    CCDS7249.1
    UniProtKB/Swiss-Prot
    A6NNV6, O95229, Q0D2I3, Q9BWD0
    UniProtKB/TrEMBL
    B4DP12
    Related
    ENSP00000363055.3, ENST00000373944.8
    Conserved Domains (1) summary
    pfam15556
    Location:29 → 277
    Zwint; ZW10 interactor

  3. NM_032997.3 → NP_127490.1  ZW10 interactor isoform a

    See identical proteins and their annotated locations for NP_127490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    BC000411, BC016357, BC020979, BG615304
    Consensus CDS
    CCDS7249.1
    UniProtKB/Swiss-Prot
    A6NNV6, O95229, Q0D2I3, Q9BWD0
    UniProtKB/TrEMBL
    B4DP12
    Related
    ENSP00000378801.1, ENST00000395405.5
    Conserved Domains (1) summary
    pfam15556
    Location:29 → 277
    Zwint; ZW10 interactor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    56357227..56361273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_428692.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    57207567..57211612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008488158.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005414.1: Suppressed sequence

    Description
    NM_001005414.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95229.2 GenPept UniProtKB/Swiss-Prot:O95229

Gene LinkOut

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