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LOC111258501 MEIS1 5' regulatory region [ Homo sapiens (human) ]

Gene ID: 111258501, updated on 10-Oct-2023

Summary

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Gene symbol
LOC111258501
Gene description
MEIS1 5' regulatory region
Gene type
biological region
Feature type(s)
protein_bind
regulatory: DNase_I_hypersensitive_site, enhancer, promoter, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHc2:066543
Summary
This region represents the promoter and a nearby upstream enhancer of the Meis homeobox 1 gene. Both the promoter and enhancer correspond to DNase I hypersensitive sites. The promoter region can act as an enhancer on a heterologous promoter and drive expression of a transgene in the developing nervous system. Activity of this sequence is induced by association of Spi-1 proto-oncogene and E74 like ETS transcription factor 1. This region has been found to be epigenetically silenced by DNA methylation in tumor cells. This locus also includes two accessible chromatin subregions, one of which was validated as an enhancer and the other as a silencer based on their ability to activate or repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (66433299..66435854)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (66442379..66444932)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (66660431..66662986)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 4778 Neighboring gene E4 enhancer upstream of MEIS1 Neighboring gene Sharpr-MPRA regulatory region 4056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:66617956-66618568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:66618569-66619179 Neighboring gene long intergenic non-protein coding RNA 1873 Neighboring gene MEIS1 antisense RNA 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:66666573-66667772 Neighboring gene HHc2:066588 enhancer in MEIS1 Neighboring gene E2 enhancer in MEIS1 Neighboring gene MEIS1 antisense RNA 2 Neighboring gene Meis homeobox 1 Neighboring gene E5 enhancer in MEIS1 Neighboring gene HHc2:066628 enhancer in MEIS1 Neighboring gene E7 enhancer in MEIS1 Neighboring gene HCNR606 enhancer in MEIS1 Neighboring gene uncharacterized LOC124900511 Neighboring gene HCNR617 enhancer in MEIS1 Neighboring gene HHc2:066650 enhancer in MEIS1 Neighboring gene HHc2:066659 enhancer in MEIS1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 15940
  • ATAC-STARR-seq lymphoblastoid silent region 11585
  • E1 -2kb enhancer of MEIS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055597.1 

    Range
    101..2656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    66433299..66435854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    66442379..66444932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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