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LOC111216273 ADH1B promoter [ Homo sapiens (human) ]

Gene ID: 111216273, updated on 10-Oct-2023

Summary

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Gene symbol
LOC111216273
Gene description
ADH1B promoter
Gene type
biological region
Feature type(s)
protein_bind
regulatory: TATA_box, enhancer, promoter
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the promoter of the alcohol dehydrogenase 1B (class I), beta polypeptide (ADH1B) gene, also known as ADH2. This promoter is regulated by binding by CCAAT/enhancer binding protein to sites conserved in members of this gene family. Activity of this region is also induced by glucocorticoids and bile acids through binding of nuclear receptor family members to multiple sites in this sequence. This promoter is negatively regulated by cytosine methylation. [provided by RefSeq, Oct 2017]
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Genomic context

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Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (99321367..99321673)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (102636148..102636454)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100242524..100242830)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507053 Neighboring gene NANOG hESC enhancer GRCh37_chr4:100126223-100126724 Neighboring gene ADH6 promoter Neighboring gene alcohol dehydrogenase 6 (class V) Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:100207424-100208623 Neighboring gene ADH1A promoter Neighboring gene alcohol dehydrogenase 1A (class I), alpha polypeptide Neighboring gene NANOG hESC enhancer GRCh37_chr4:100231513-100232014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:100238861-100240060 Neighboring gene alcohol dehydrogenase 1B (class I), beta polypeptide Neighboring gene ADH1C promoter region Neighboring gene alcohol dehydrogenase 1C (class I), gamma polypeptide Neighboring gene uncharacterized LOC102723576 Neighboring gene D-E enhancer region downstream of ADH7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-specific differences in the expression of the human ADH2 alcohol dehydrogenase gene and in binding of factors to cis-acting elements in its promoter. Brown CJ, et al. DNA Cell Biol, 1994 Mar. PMID 8172654
  2. trans activation of human alcohol dehydrogenase gene expression in hepatoma cells by C/EBP molecules bound in a novel arrangement just 5' and 3' to the TATA box. Stewart MJ, et al. Mol Cell Biol, 1990 Sep. PMID 2167445, Free PMC Article
  3. Variation in the ADH1B proximal promoter affects expression. Pochareddy S, et al. Chem Biol Interact, 2011 May 30. PMID 21168396, Free PMC Article
  4. Molecular analysis of the human class I alcohol dehydrogenase gene family and nucleotide sequence of the gene encoding the beta subunit. Duester G, et al. J Biol Chem, 1986 Feb 15. PMID 2935533
  5. Nucleotide sequence of the ADH2(3) gene encoding the human alcohol dehydrogenase beta 3 subunit. Carr LG, et al. Alcohol Clin Exp Res, 1989 Aug. PMID 2679216

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055569.1 

    Range
    101..407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    99321367..99321673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    102636148..102636454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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