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EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 [ Delphinapterus leucas (beluga whale) ]

Gene ID: 111184654, updated on 15-Mar-2024

Summary

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Gene symbol
EDEM3
Gene description
ER degradation enhancing alpha-mannosidase like protein 3
See related
Ensembl:ENSDLEG00000020763
Gene type
protein coding
RefSeq status
MODEL
Organism
Delphinapterus leucas
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Delphinapterus
Orthologs
human mouse all
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Genomic context

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See EDEM3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
22
Annotation release Status Assembly Chr Location
101 current ASM228892v3 (GCF_002288925.2) Unplaced Scaffold NW_022098019.1 (9402039..9490878, complement)
100 previous assembly ASM228892v2 (GCF_002288925.1) Unplaced Scaffold NW_019160903.1 (2022243..2111082, complement)

NW_022098019.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase PLK1 pseudogene Neighboring gene uncharacterized LOC111184653 Neighboring gene niban apoptosis regulator 1 Neighboring gene reactive oxygen species modulator 1 pseudogene Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endoplasmic reticulum mannose trimming IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mannose trimming involved in glycoprotein ERAD pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ER degradation-enhancing alpha-mannosidase-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Delphinapterus leucas Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM228892v3 Primary Assembly

Genomic

  1. NW_022098019.1 Reference ASM228892v3 Primary Assembly

    Range
    9402039..9490878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022593360.2 → XP_022449068.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A2Y9Q0X3
    Related
    ENSDLEP00000029014.1, ENSDLET00000031862.1
    Conserved Domains (3) summary
    cd02126
    Location:665 → 790
    PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
    pfam01532
    Location:60 → 499
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl27702
    Location:810 → 937
    COG3942; Surface antigen [Cell wall/membrane/envelope biogenesis]

  2. XM_022593358.2 → XP_022449066.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9PV38
    Related
    ENSDLEP00000029034.1, ENSDLET00000031882.1
    Conserved Domains (3) summary
    cd02126
    Location:665 → 790
    PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
    pfam01532
    Location:60 → 499
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl27702
    Location:805 → 921
    COG3942; Surface antigen [Cell wall/membrane/envelope biogenesis]

  3. XM_022593356.2 → XP_022449064.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0W8
    Conserved Domains (3) summary
    cd02126
    Location:666 → 791
    PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
    pfam01532
    Location:60 → 499
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl27702
    Location:806 → 922
    COG3942; Surface antigen [Cell wall/membrane/envelope biogenesis]

  4. XM_022593359.2 → XP_022449067.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9Q0L2
    Conserved Domains (3) summary
    cd02126
    Location:598 → 723
    PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
    pfam01532
    Location:1 → 431
    Glyco_hydro_47; Glycosyl hydrolase family 47
    cl27702
    Location:738 → 854
    COG3942; Surface antigen [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
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