LOC111162620 TAp63 promoter of tumor protein p63 [Homo sapiens (human)] - Gene

Summary

Gene symbol: LOC111162620
Gene description: TAp63 promoter of tumor protein p63
Gene type: biological region
Feature type(s): protein_bind
regulatory: promoter, transcriptional_cis_regulatory_region
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This region represents the promoter of the TAp63 alternate variant of the tumor protein p63 gene. This promoter is regulated by binding of nuclear factor kappa B to this region, and may also be induced by AP1 family members and POU class 5 homeobox 1. [provided by RefSeq, Sep 2017]
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Genomic context

Location:: chromosome: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (189630704..189631513)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (192447395..192448204)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (189348493..189349302)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAp63 expression was significantly lower in type 2 diabetes mellitus (T2DM) patients compared with that of the controls, and may be correlated with chronic inflammatory state and perturbed glucose and lipid metabolism in T2DM.
Title: TAp63 is correlated with chronic inflammation in patients with newly diagnosed type 2 diabetes mellitus.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.