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HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 [ Homo sapiens (human) ]

Gene ID: 11100, updated on 7-Apr-2024

Summary

Official Symbol
HNRNPUL1provided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein U like 1provided by HGNC
Primary source
HGNC:HGNC:17011
See related
Ensembl:ENSG00000105323 MIM:605800; AllianceGenome:HGNC:17011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E1BAP5; E1B-AP5; HNRPUL1
Summary
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in testis (RPKM 41.5), ovary (RPKM 40.7) and 25 other tissues See more
Orthologs
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Genomic context

See HNRNPUL1 in Genome Data Viewer
Location:
19q13.2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41262557..41307787)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44083416..44128645)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41768462..41813692)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41698650-41699150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41700461-41700973 Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41712923-41713700 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41718918-41719078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41724269-41725093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41727344-41728281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41730156-41731091 Neighboring gene AXL receptor tyrosine kinase Neighboring gene tRNA-Lys (anticodon TTT) 10-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:41768709-41769248 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:41769249-41769788 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41769789-41770327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10655 Neighboring gene MPRA-validated peak3484 silencer Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15507 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:41806393-41807592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14672 Neighboring gene uncharacterized LOC105372401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41825837-41826574 Neighboring gene Sharpr-MPRA regulatory regions 2264 and 10656 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41828472-41828958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41829057-41829826 Neighboring gene coiled-coil domain containing 97 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41830597-41831366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41831367-41832136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41833547-41834068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14676 Neighboring gene transforming growth factor beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10664

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPUL1 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPUL1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12944

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
PubMed 
involved_in alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to virus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein U-like protein 1
Names
E1B 55kDa associated protein 5
E1B-55 kDa-associated protein 5
adenovirus early region 1B-associated protein 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301016.3NP_001287945.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform e

    See identical proteins and their annotated locations for NP_001287945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform e, which has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS82351.1
    UniProtKB/TrEMBL
    A8K3W4, B7Z4B8
    Related
    ENSP00000263367.3, ENST00000263367.7
    Conserved Domains (3) summary
    pfam13671
    Location:334479
    AAA_33; AAA domain
    cd12884
    Location:122299
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:334472
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. NM_001321208.2NP_001308137.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12577.1
    UniProtKB/TrEMBL
    A8K3W4
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  3. NM_001321211.2NP_001308140.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12577.1
    UniProtKB/TrEMBL
    A8K3W4
    Related
    ENSP00000472629.1, ENST00000593587.5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. NM_007040.6NP_008971.2  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_008971.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12576.1
    UniProtKB/Swiss-Prot
    B3KMW7, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9BUJ2, Q9HAL3, Q9UG75
    UniProtKB/TrEMBL
    A8K6U7
    Related
    ENSP00000375863.2, ENST00000392006.8
    Conserved Domains (4) summary
    smart00513
    Location:337
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:423568
    AAA_33; AAA domain
    cd12884
    Location:211388
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:423561
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. NM_144732.5NP_653333.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_653333.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1, resulting in an isoform (d) that maintains the reading frame but is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC011462, AC011510
    Consensus CDS
    CCDS12577.1
    UniProtKB/TrEMBL
    A8K3W4
    Related
    ENSP00000473132.1, ENST00000595018.5
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41262557..41307787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258464.5XP_005258521.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005258521.1

    UniProtKB/TrEMBL
    A0A0A0MRA5, A8K3W4
    Related
    ENSP00000340857.3, ENST00000352456.7
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. XM_047438115.1XP_047294071.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X7

    Related
    ENSP00000473178.1, ENST00000599614.5
  3. XM_011526395.4XP_011524697.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011524697.1

    UniProtKB/TrEMBL
    A0A0A0MRA5, A8K3W4
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. XM_011526393.4XP_011524695.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011524695.1

    UniProtKB/TrEMBL
    A0A0A0MRA5, A8K3W4
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  5. XM_005258459.5XP_005258516.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A8K6U7
    Related
    ENSP00000367460.3, ENST00000378215.8
    Conserved Domains (4) summary
    smart00513
    Location:337
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:423568
    AAA_33; AAA domain
    cd12884
    Location:211388
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:423561
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  6. XM_011526392.4XP_011524694.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A8K6U7
    Conserved Domains (4) summary
    smart00513
    Location:337
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam13671
    Location:423568
    AAA_33; AAA domain
    cd12884
    Location:211388
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:423561
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  7. XM_005258463.5XP_005258520.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005258520.1

    UniProtKB/TrEMBL
    A0A0A0MRA5, A8K3W4
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  8. XM_011526394.4XP_011524696.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011524696.1

    UniProtKB/TrEMBL
    A0A0A0MRA5, A8K3W4
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  9. XM_005258461.6XP_005258518.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A8K3W4
    Conserved Domains (3) summary
    pfam13671
    Location:334479
    AAA_33; AAA domain
    cd12884
    Location:122299
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:334472
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  10. XM_047438114.1XP_047294070.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X6

  11. XM_005258465.6XP_005258522.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_005258522.1

    UniProtKB/TrEMBL
    A0A0A0MRA5, A8K3W4
    Conserved Domains (3) summary
    pfam13671
    Location:323468
    AAA_33; AAA domain
    cd12884
    Location:111288
    SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
    cl17190
    Location:323461
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  12. XM_047438113.1XP_047294069.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44083416..44128645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319662.1XP_054175637.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRA5
  2. XM_054319670.1XP_054175645.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X7

  3. XM_054319666.1XP_054175641.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRA5
  4. XM_054319665.1XP_054175640.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRA5
  5. XM_054319659.1XP_054175634.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

  6. XM_054319660.1XP_054175635.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

  7. XM_054319664.1XP_054175639.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRA5
  8. XM_054319667.1XP_054175642.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRA5
  9. XM_054319663.1XP_054175638.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRA5
  10. XM_054319668.1XP_054175643.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X5

  11. XM_054319661.1XP_054175636.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X3

  12. XM_054319669.1XP_054175644.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144733.1: Suppressed sequence

    Description
    NM_144733.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_144734.1: Suppressed sequence

    Description
    NM_144734.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.