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Ptpa protein phosphatase 2 protein activator [ Mus musculus (house mouse) ]

Gene ID: 110854, updated on 14-Nov-2024

Summary

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Official Symbol
Ptpaprovided by MGI
Official Full Name
protein phosphatase 2 protein activatorprovided by MGI
Primary source
MGI:MGI:1346006
See related
Ensembl:ENSMUSG00000039515 AllianceGenome:MGI:1346006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR53; Ppp2r4; 2610042B21Rik
Summary
Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in mitotic spindle organization and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of ATPase complex; calcium channel complex; and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 63.8), liver E14.5 (RPKM 52.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ptpa in Genome Data Viewer
Location:
2 B; 2 21.71 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30306062..30337819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30416050..30447807)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitoguardin 2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5903 Neighboring gene STARR-seq mESC enhancer starr_04096 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:30319437-30319638 Neighboring gene STARR-positive B cell enhancer ABC_E1584 Neighboring gene STARR-positive B cell enhancer ABC_E3367 Neighboring gene predicted gene, 31291 Neighboring gene immediate early response 5-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis. Jayappa KD, et al. J Clin Invest, 2023 Jul 3. PMID 37166997, Free PMC Article
  2. Ifenprodil Attenuates Methamphetamine-Induced Behavioral Sensitization Through the GluN2B-PP2A-AKT Cascade in the Dorsal Striatum of Mice. Chen G, et al. Neurochem Res, 2020 Apr. PMID 31981057
  3. UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology. Wang J, et al. Proc Natl Acad Sci U S A, 2019 Jun 18. PMID 31160454, Free PMC Article
  4. Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein. Kurihara D, et al. J Biol Chem, 2012 Apr 20. PMID 22389491, Free PMC Article
  5. Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis. Azam S, et al. Apoptosis, 2007 Jul. PMID 17333320

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
    Title: PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
  2. results implicate a critical role of UBE3A-PTPA-PP2A signaling in the pathogenesis of UBE3A-related disorders and suggest that PP2A-based drugs could be potential therapeutic candidates for treatment of UBE3A-related disorders
    Title: UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology.
  3. Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A inhibition in human cancer.
    Title: PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.
  4. data indicate that PTPalpha and FAK, which are enriched in FAs, interact with IP3R1 at adjacent ER sites to spatially sequester IL-1-induced Ca(2+) signalling
    Title: A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts.
  5. oxidative stress regulates the phosphorylation status of nonribosomal rpS3 by both activating PKCdelta and blocking the PP2A interaction with rpS3
    Title: Phosphorylation status of nuclear ribosomal protein S3 is reciprocally regulated by protein kinase C{delta} and protein phosphatase 2A.
  6. findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3-dependent apoptosis
    Title: Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7129, MGC60706

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to phosphoprotein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2A binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of ATPase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A activator
Names
phosphotyrosyl phosphatase activator
protein phosphatase 2A activator, regulatory subunit B
protein phosphatase 2A, regulatory subunit B (PR 53)
serine/threonine-protein phosphatase 2A regulatory subunit 4
serine/threonine-protein phosphatase 2A regulatory subunit B'
NP_001349662.1
NP_001349663.1
NP_620087.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362733.1 → NP_001349662.1  serine/threonine-protein phosphatase 2A activator isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL954299
    UniProtKB/TrEMBL
    Q8C0E1
    Conserved Domains (1) summary
    pfam03095
    Location:26 → 319
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

  2. NM_001362734.1 → NP_001349663.1  serine/threonine-protein phosphatase 2A activator isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL954299
    Conserved Domains (1) summary
    pfam03095
    Location:26 → 229
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

  3. NM_138748.5 → NP_620087.3  serine/threonine-protein phosphatase 2A activator isoform 2

    See identical proteins and their annotated locations for NP_620087.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK049184, AL954299
    Consensus CDS
    CCDS15883.1
    UniProtKB/Swiss-Prot
    P58389
    UniProtKB/TrEMBL
    Q543N6, Q8C0E1
    Related
    ENSMUSP00000046837.4, ENSMUST00000042055.10
    Conserved Domains (1) summary
    pfam03095
    Location:26 → 316
    PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

RNA

  1. NR_156126.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954299

  2. NR_156127.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954299, CX221557

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30306062..30337819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58389.1 GenPept UniProtKB/Swiss-Prot:P58389

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