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LOC110599592 CYP3A5 promoter [ Homo sapiens (human) ]

Gene ID: 110599592, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110599592
Gene description
CYP3A5 promoter
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents the proximal promoter of the cytochrome P450 family 3 subfamily A member 5 (CYP3A5) gene. This promoter is induced by xenobiotics, vitamin D, and androgen, through binding of nuclear receptor subfamily 1 group I members, nuclear transcription factor Y, and Sp1/Sp3 transcription factors to this sequence. The 5' regulatory regions of CYP3 family members, including CYP3A4 and CYP3A5, are similar at the sequence level but have subtle differences in function. [provided by RefSeq, Jul 2017]
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Genomic context

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See LOC110599592 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99679916..99680749)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100919436..100920269)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99277539..99278372)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 225B Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99213715-99214694 Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99227460-99228106 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99236540-99236705 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene cytochrome P450 family 3 subfamily A member 51, pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene CYP3A7 5' regulatory region

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Statin regulation of CYP3A4 and CYP3A5 expression. Willrich MA, et al. Pharmacogenomics, 2009 Jun. PMID 19530969
  2. Characterization of androgen-regulated expression of CYP3A5 in human prostate. Moilanen AM, et al. Carcinogenesis, 2007 May. PMID 17116727
  3. Apparent low frequency of sequence variability within the proximal promoter region of the cytochrome P450 (CYP) 3A5 gene in established cell lines from Japanese individuals. Nakamura T, et al. Biol Pharm Bull, 2001 Aug. PMID 11510493
  4. Cooperative regulation of CYP3A5 gene transcription by NF-Y and Sp family members. Iwano S, et al. Biochem Biophys Res Commun, 2001 Aug 10. PMID 11485307
  5. Regulation of CYP3A4 and CYP3A5 expression and modulation of "intracrine" metabolism of androgens in prostate cells by liganded vitamin D receptor. Maguire O, et al. Mol Cell Endocrinol, 2012 Nov 25. PMID 22939842

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055450.1 

    Range
    101..934
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99679916..99680749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100919436..100920269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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