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ASDURF ASNSD1 upstream open reading frame [ Homo sapiens (human) ]

Gene ID: 110599588, updated on 15-Mar-2024

Summary

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Official Symbol
ASDURFprovided by HGNC
Official Full Name
ASNSD1 upstream open reading frameprovided by HGNC
Primary source
HGNC:HGNC:53619
See related
Ensembl:ENSG00000286053 MIM:619740; AllianceGenome:HGNC:53619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASNSD1; NS3TP1; ASNSD1-SEP
Summary
Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ASDURF in Genome Data Viewer
Location:
2q32.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (189661459..189666401)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (190150718..190155647)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (190526185..190531127)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene KDM3A pseudogene 1 Neighboring gene solute carrier family 40 member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16851 Neighboring gene uncharacterized LOC105373793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16852 Neighboring gene asparagine synthetase domain containing 1 Neighboring gene ankyrin and armadillo repeat containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16853 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:190627447-190628193 Neighboring gene OSGEPL1 antisense RNA 1 Neighboring gene O-sialoglycoprotein endopeptidase like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of sORF-encoded polypeptides. Chu Q, et al. Crit Rev Biochem Mol Biol, 2015 Mar-Apr. PMID 25857697, Free PMC Article
  2. Peptidomic discovery of short open reading frame-encoded peptides in human cells. Slavoff SA, et al. Nat Chem Biol, 2013 Jan. PMID 23160002, Free PMC Article
  3. Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome. Cloutier P, et al. J Proteome Res, 2020 Jan 3. PMID 31738558
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASDURF is a beta prefoldin and a subunit of the prefoldin-like module of the PAQosome/R2TP-PFDL complex.
    Title: Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in protein stabilization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ASNSD1 upstream open reading frame protein
Names
ASNSD1 upstream reading frame
Asparagine synthetase domain-containing protein 1
HCV NS3-transactivated protein 1
alternative protein ASNSD1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353493.2 → NP_001340422.1  ASNSD1 upstream open reading frame protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC012488, BF508929
    Consensus CDS
    CCDS86901.1
    UniProtKB/Swiss-Prot
    L0R819
    Related
    ENSP00000475224.1, ENST00000607829.6

  2. NM_001353494.2 → NP_001340423.1  ASNSD1 upstream open reading frame protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012488, BM670756
    Consensus CDS
    CCDS86902.1
    UniProtKB/TrEMBL
    U3KQ49
    Related
    ENSP00000475546.1, ENST00000607690.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    189661459..189666401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    190150718..190155647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
L0R819.1 GenPept UniProtKB/Swiss-Prot:L0R819

Gene LinkOut

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