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LOC110599577 XREM-like enhancer of CYP2B6 [ Homo sapiens (human) ]

Gene ID: 110599577, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110599577
Gene description
XREM-like enhancer of CYP2B6
Gene type
biological region
Feature type(s)
protein_bind
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents an upstream xenobiotic-responsive enhancer of the cytochrome P450 family 2 subfamily B member 6 (Cyp2B6) gene. Activity of this enhancer is stimulated by binding of nuclear receptor subfamily 1 group I family members. [provided by RefSeq, Jul 2017]
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Genomic context

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See LOC110599577 in Genome Data Viewer
Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40982528..40982938)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43803436..43803846)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41488433..41488843)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12493 Neighboring gene cytochrome P450 family 2 subfamily G member 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10651 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41426957-41427227 Neighboring gene cytochrome P450 family 2 subfamily B member 7, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41486817-41487680 Neighboring gene CYP2B6 promoter-proximal regulatory region Neighboring gene cytochrome P450 family 2 subfamily B member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41532560-41533088 Neighboring gene cytochrome P450 family 2 subfamily A member 7 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional regulation of cytochrome p450 2B genes by nuclear receptors. Wang H, et al. Curr Drug Metab, 2003 Dec. PMID 14683479
  2. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor. Faucette SR, et al. J Pharmacol Exp Ther, 2006 Jun. PMID 16513849
  3. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. Wang H, et al. J Biol Chem, 2003 Apr 18. PMID 12571232
  4. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. Casabar RC, et al. Toxicol Appl Pharmacol, 2010 Jun 15. PMID 20361990
  5. CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model. Benet M, et al. J Biol Chem, 2010 Sep 10. PMID 20622021, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055441.1 

    Range
    101..511
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40982528..40982938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43803436..43803846
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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