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LOC110599575 CYP2B6 promoter-proximal regulatory region [ Homo sapiens (human) ]

Gene ID: 110599575, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110599575
Gene description
CYP2B6 promoter-proximal regulatory region
Gene type
biological region
Feature type(s)
misc_feature: sequence_alteration
protein_bind
regulatory: TATA_box, enhancer, promoter, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBREM
Summary
This region represents the promoter and nearby 5' regulatory elements of the cytochrome P450 family 2 subfamily B member 6 (CYP2B6) gene. This region is stimulated synergistically through association of nuclear receptor subfamily 1 group I family members, vitamin D receptor, hepatocyte nuclear factor 4 alpha, early growth response 1, CCAAT/enhancer binding proteins, and estrogen receptor to recognition sites in this sequence. Chromatin conformation capture experiments suggest that binding modules in this region may form three-dimensional loops during activation of transcription. Naturally-occurring sequence variation in this region can alter binding sites and thereby affect promoter activity. [provided by RefSeq, Jul 2017]
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Genomic context

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Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40989053..40991321)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43809961..43812230)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41494958..41497226)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12493 Neighboring gene cytochrome P450 family 2 subfamily G member 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10651 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41426957-41427227 Neighboring gene cytochrome P450 family 2 subfamily B member 7, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41486817-41487680 Neighboring gene XREM-like enhancer of CYP2B6 Neighboring gene cytochrome P450 family 2 subfamily B member 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41532560-41533088 Neighboring gene cytochrome P450 family 2 subfamily A member 7 pseudogene 1 Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insights into CYP2B6-mediated drug-drug interactions. Hedrich WD, et al. Acta Pharm Sin B, 2016 Sep. PMID 27709010, Free PMC Article
  2. Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells. Li L, et al. PLoS One, 2016. PMID 26930610, Free PMC Article
  3. Electrophoretic Mobility Shift Assay (EMSA) and Supershift Assay of Cytochrome P450 2B6 in Response to Estrogen. Koh KH, et al. Methods Mol Biol, 2016. PMID 26585126
  4. Involvement of CAR and PXR in the transcriptional regulation of CYP2B6 gene expression by ingredients from herbal medicines. Xu C, et al. Xenobiotica, 2015. PMID 25869249
  5. Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy. Koh KH, et al. Biochem Pharmacol, 2012 Jul 1. PMID 22484313, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • CYP2B6 phenobarbital-responsive enhancer module

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055439.1 

    Range
    101..2369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40989053..40991321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43809961..43812230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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