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LOC110596865 16p subtelomeric meiotic recombination hotspot [ Homo sapiens (human) ]

Gene ID: 110596865, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110596865
Gene description
16p subtelomeric meiotic recombination hotspot
Gene type
biological region
Feature type(s)
misc_feature: nucleotide_motif
misc_recomb: meiotic
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region is found in the subtelomeric region of chromosome 16 on the p arm, and has been identified as a meiotic recombination hotspot by molecular assays in male germ cells. Meiotic hotspot activity can vary widely amongst individuals and is partly influenced by both the nucleotide sequence at the meiotic recombination hotspot and the specific alleles present at the PR domain 9 (PRDM9) locus. [provided by RefSeq, Jul 2017]
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Genomic context

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Location:
16p13.3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1125590..1129030)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1138244..1141684)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1175590..1179030)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6964 Neighboring gene uncharacterized LOC107984906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1157970-1158488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1167285-1167853 Neighboring gene uncharacterized LOC105371042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1188009-1188509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1194132-1194948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1194949-1195763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1202005-1202585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1203960-1204727 Neighboring gene uncharacterized LOC124903622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1208711-1209430 Neighboring gene calcium voltage-gated channel subunit alpha1 H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1213358-1213914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1222787-1223288 Neighboring gene MS205 minisatellite repeat instability region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1248019-1248578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1248579-1249136 Neighboring gene uncharacterized LOC124903623

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination. Badge RM, et al. Hum Mol Genet, 2000 May 1. PMID 10767349
  2. Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. Berg IL, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21750151, Free PMC Article
  3. A common sequence motif associated with recombination hot spots and genome instability in humans. Myers S, et al. Nat Genet, 2008 Sep. PMID 19165926
  4. DNA recombination. Recombination initiation maps of individual human genomes. Pratto F, et al. Science, 2014 Nov 14. PMID 25395542, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055428.1 

    Range
    101..3541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1125590..1129030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1138244..1141684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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