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WWP1 WW domain containing E3 ubiquitin protein ligase 1 [ Homo sapiens (human) ]

Gene ID: 11059, updated on 11-Apr-2024

Summary

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Official Symbol
WWP1provided by HGNC
Official Full Name
WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
Primary source
HGNC:HGNC:17004
See related
Ensembl:ENSG00000123124 MIM:602307; AllianceGenome:HGNC:17004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP5; Tiul1; hSDRP1
Summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues See more
Orthologs
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Genomic context

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See WWP1 in Genome Data Viewer
Location:
8q21.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (86342547..86468503)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (87462833..87588744)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (87354776..87480732)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375623 Neighboring gene solute carrier family 7 member 13 Neighboring gene HNF4 motif-containing MPRA enhancer 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19341 Neighboring gene WWP1 antisense RNA 1 Neighboring gene regulator of microtubule dynamics 1 Neighboring gene N-terminal asparagine amidase pseudogene 2 Neighboring gene solute carrier family 2 member 3 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High Expression of WWP1 Associates with Tumor Progression in Papillary Thyroid Cancer. Wang X, et al. Cancer Biother Radiopharm, 2022 May. PMID 34388030
  2. [Abnormal expression of WWP1 in chronic lymphocytic leukemia and its clinical significance]. Yang CQ, et al. Zhonghua Xue Ye Xue Za Zhi, 2020 Sep 14. PMID 33113605, Free PMC Article
  3. WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. Lee YR, et al. N Engl J Med, 2020 May 28. PMID 32459922, Free PMC Article
  4. WW domain-containing E3 ubiquitin protein ligase 1 depletion evokes antitumor effect in cutaneous squamous cell carcinoma by inhibiting signal transducer and activator of transcription 3 signaling pathway. Xia Y, et al. J Int Med Res, 2018 Jul. PMID 29888632, Free PMC Article
  5. The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia. Sanarico AG, et al. Leukemia, 2018 Apr. PMID 29209041, Free PMC Article

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High Expression of WWP1 Associates with Tumor Progression in Papillary Thyroid Cancer.
    Title: High Expression of WWP1 Associates with Tumor Progression in Papillary Thyroid Cancer.
  2. alpha-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer.
    Title: α-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer.
  3. WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis.
    Title: WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis.
  4. miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/beta-catenin signaling pathway.
    Title: miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway.
  5. AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
    Title: AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
  6. WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.
    Title: WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.
  7. Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
    Title: Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
  8. Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy.
    Title: Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy.
  9. CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway.
    Title: CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway.
  10. BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression.
    Title: BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression.
Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434D2111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in central nervous system development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in monoatomic ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in symbiont entry into host cell TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
NEDD4-like E3 ubiquitin-protein ligase WWP1
Names
HECT-type E3 ubiquitin transferase WWP1
Nedd-4-like ubiquitin-protein ligase
TGIF-interacting ubiquitin ligase 1
WW domain-containing protein 1
atrophin-1 interacting protein 5
NP_008944.1
XP_005250817.1
XP_005250818.1
XP_016868482.1
XP_016868483.1
XP_024302824.1
XP_047277238.1
XP_047277239.1
XP_047277240.1
XP_047277241.1
XP_054215606.1
XP_054215607.1
XP_054215608.1
XP_054215609.1
XP_054215610.1
XP_054215611.1
XP_054215612.1
XP_054215613.1
XP_054215614.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007013.4 → NP_008944.1  NEDD4-like E3 ubiquitin-protein ligase WWP1

    See identical proteins and their annotated locations for NP_008944.1

    Status: VALIDATED

    Source sequence(s)
    AC103760, AC103817, AW137654, AY043361, BC036065, BM664090
    Consensus CDS
    CCDS6242.1
    UniProtKB/Swiss-Prot
    O00307, Q5YLC1, Q96BP4, Q9H0M0
    UniProtKB/TrEMBL
    A8K9T5
    Related
    ENSP00000427793.1, ENST00000517970.6
    Conserved Domains (2) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:307 → 922
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    86342547..86468503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447056.2 → XP_024302824.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

    UniProtKB/TrEMBL
    A8K9T5
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:559 → 896
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:499 → 528
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:351 → 380
    WW; WW domain

  2. XM_005250761.5 → XP_005250818.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

    UniProtKB/TrEMBL
    A8K9T5
    Conserved Domains (6) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:590 → 918
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:567 → 919
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:498 → 527
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:350 → 379
    WW; WW domain
    pfam07010
    Location:201 → 326
    Endomucin; Endomucin

  3. XM_047421282.1 → XP_047277238.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  4. XM_005250760.5 → XP_005250817.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

    See identical proteins and their annotated locations for XP_005250817.1

    UniProtKB/Swiss-Prot
    O00307, Q5YLC1, Q96BP4, Q9H0M0
    UniProtKB/TrEMBL
    A8K9T5
    Related
    ENSP00000265428.4, ENST00000265428.4
    Conserved Domains (2) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:307 → 922
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

  5. XM_017012994.3 → XP_016868483.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

    UniProtKB/TrEMBL
    A8K9T5
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    cd00078
    Location:559 → 896
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:499 → 528
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:351 → 380
    WW; WW domain

  6. XM_017012993.2 → XP_016868482.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

    UniProtKB/TrEMBL
    A8K9T5
    Conserved Domains (6) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    smart00119
    Location:590 → 918
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:567 → 919
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00201
    Location:498 → 527
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:350 → 379
    WW; WW domain
    pfam07010
    Location:201 → 326
    Endomucin; Endomucin

  7. XM_047421283.1 → XP_047277239.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  8. XM_047421285.1 → XP_047277241.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X6

  9. XM_047421284.1 → XP_047277240.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    87462833..87588744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359634.1 → XP_054215609.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

  2. XM_054359632.1 → XP_054215607.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

  3. XM_054359636.1 → XP_054215611.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  4. XM_054359631.1 → XP_054215606.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

    UniProtKB/Swiss-Prot
    O00307, Q5YLC1, Q96BP4, Q9H0M0

  5. XM_054359635.1 → XP_054215610.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

  6. XM_054359633.1 → XP_054215608.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

  7. XM_054359637.1 → XP_054215612.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4

  8. XM_054359639.1 → XP_054215614.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X6

  9. XM_054359638.1 → XP_054215613.1  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H0M0.1 GenPept UniProtKB/Swiss-Prot:Q9H0M0

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