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DYSF dysferlin [ Neomonachus schauinslandi (Hawaiian monk seal) ]

Gene ID: 110588701, updated on 15-Mar-2024

Summary

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Gene symbol
DYSF
Gene description
dysferlin
See related
EnsemblRapid:ENSNSCG00000022922
Gene type
protein coding
RefSeq status
MODEL
Organism
Neomonachus schauinslandi
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Neomonachus
Orthologs
human mouse all
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Genomic context

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See DYSF in Genome Data Viewer
Location:
chromosome: 10
Exon count:
58
Annotation release Status Assembly Chr Location
101 current ASM220157v2 (GCF_002201575.2) 10 NC_058412.1 (50691653..50894767, complement)
100 previous assembly ASM220157v1 (GCF_002201575.1) Unplaced Scaffold NW_018734379.1 (8601553..8804691, complement)

Chromosome 10 - NC_058412.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 26B1 Neighboring gene U2 spliceosomal RNA Neighboring gene 39S ribosomal protein L18, mitochondrial-like Neighboring gene zinc finger protein 638 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-tubule organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monocyte activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dysferlin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Neomonachus schauinslandi Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM220157v2

Genomic

  1. NC_058412.1 Reference ASM220157v2

    Range
    50691653..50894767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021699074.1 → XP_021554749.1  dysferlin isoform X14

    UniProtKB/TrEMBL
    A0A2Y9HY08
    Conserved Domains (11) summary
    cd04011
    Location:219 → 328
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1140 → 1268
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:382 → 542
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1567 → 1690
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1801 → 1932
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:934 → 990
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:775 → 847
    FerB; FerB (NUC096) domain
    pfam08151
    Location:326 → 376
    FerI; FerI (NUC094) domain
    pfam08165
    Location:686 → 743
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1945 → 2032
    Ferlin_C; Ferlin C-terminus

  2. XM_021699070.1 → XP_021554745.1  dysferlin isoform X10

    UniProtKB/TrEMBL
    A0A2Y9HZJ1
    Conserved Domains (11) summary
    cd04011
    Location:219 → 328
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1140 → 1268
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:382 → 542
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1588 → 1711
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1822 → 1953
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:934 → 990
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:775 → 847
    FerB; FerB (NUC096) domain
    pfam08151
    Location:326 → 376
    FerI; FerI (NUC094) domain
    pfam08165
    Location:686 → 743
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1966 → 2053
    Ferlin_C; Ferlin C-terminus

  3. XM_021699072.1 → XP_021554747.1  dysferlin isoform X12

    UniProtKB/TrEMBL
    A0A2Y9HT38
    Conserved Domains (11) summary
    cd04011
    Location:219 → 328
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1154 → 1282
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:382 → 556
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1581 → 1704
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1815 → 1946
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:948 → 1004
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:789 → 861
    FerB; FerB (NUC096) domain
    pfam08151
    Location:326 → 376
    FerI; FerI (NUC094) domain
    pfam08165
    Location:700 → 757
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1959 → 2046
    Ferlin_C; Ferlin C-terminus

  4. XM_021699068.1 → XP_021554743.1  dysferlin isoform X8

    UniProtKB/TrEMBL
    A0A2Y9HSM2
    Conserved Domains (11) summary
    cd04011
    Location:219 → 328
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1154 → 1282
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:382 → 556
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1602 → 1725
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1836 → 1967
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:948 → 1004
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:789 → 861
    FerB; FerB (NUC096) domain
    pfam08151
    Location:326 → 376
    FerI; FerI (NUC094) domain
    pfam08165
    Location:700 → 757
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1980 → 2067
    Ferlin_C; Ferlin C-terminus

  5. XM_021699065.1 → XP_021554740.1  dysferlin isoform X6

    UniProtKB/TrEMBL
    A0A2Y9HZI3
    Conserved Domains (11) summary
    cd04011
    Location:250 → 359
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1171 → 1299
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:413 → 573
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1598 → 1721
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1832 → 1963
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:965 → 1021
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:806 → 878
    FerB; FerB (NUC096) domain
    pfam08151
    Location:357 → 407
    FerI; FerI (NUC094) domain
    pfam08165
    Location:717 → 774
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1976 → 2063
    Ferlin_C; Ferlin C-terminus

  6. XM_021699061.1 → XP_021554736.1  dysferlin isoform X2

    UniProtKB/TrEMBL
    A0A2Y9HT40
    Related
    ENSNSCP00000029195.1, ENSNSCT00000032835.1
    Conserved Domains (11) summary
    cd04011
    Location:250 → 359
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1171 → 1299
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:413 → 573
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1619 → 1742
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1853 → 1984
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:965 → 1021
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:806 → 878
    FerB; FerB (NUC096) domain
    pfam08151
    Location:357 → 407
    FerI; FerI (NUC094) domain
    pfam08165
    Location:717 → 774
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1997 → 2084
    Ferlin_C; Ferlin C-terminus

  7. XM_021699063.1 → XP_021554738.1  dysferlin isoform X4

    UniProtKB/TrEMBL
    A0A2Y9HSL6
    Conserved Domains (11) summary
    cd04011
    Location:250 → 359
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1185 → 1313
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:413 → 587
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1612 → 1735
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1846 → 1977
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:979 → 1035
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:820 → 892
    FerB; FerB (NUC096) domain
    pfam08151
    Location:357 → 407
    FerI; FerI (NUC094) domain
    pfam08165
    Location:731 → 788
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1990 → 2077
    Ferlin_C; Ferlin C-terminus

  8. XM_021699073.1 → XP_021554748.1  dysferlin isoform X13

    UniProtKB/TrEMBL
    A0A2Y9HSM7
    Conserved Domains (11) summary
    cd04011
    Location:220 → 329
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1141 → 1269
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:383 → 543
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1568 → 1691
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1802 → 1933
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:935 → 991
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:776 → 848
    FerB; FerB (NUC096) domain
    pfam08151
    Location:327 → 377
    FerI; FerI (NUC094) domain
    pfam08165
    Location:687 → 744
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1946 → 2033
    Ferlin_C; Ferlin C-terminus

  9. XM_021699069.1 → XP_021554744.1  dysferlin isoform X9

    UniProtKB/TrEMBL
    A0A2Y9HY04
    Conserved Domains (11) summary
    cd04011
    Location:220 → 329
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1141 → 1269
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:383 → 543
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1589 → 1712
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:8 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1823 → 1954
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:935 → 991
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:776 → 848
    FerB; FerB (NUC096) domain
    pfam08151
    Location:327 → 377
    FerI; FerI (NUC094) domain
    pfam08165
    Location:687 → 744
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1967 → 2054
    Ferlin_C; Ferlin C-terminus

  10. XM_021699071.1 → XP_021554746.1  dysferlin isoform X11

    UniProtKB/TrEMBL
    A0A2Y9HT51
    Conserved Domains (11) summary
    cd04011
    Location:220 → 329
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1155 → 1283
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:383 → 557
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1582 → 1705
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:8 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1816 → 1947
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:949 → 1005
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:790 → 862
    FerB; FerB (NUC096) domain
    pfam08151
    Location:327 → 377
    FerI; FerI (NUC094) domain
    pfam08165
    Location:701 → 758
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1960 → 2047
    Ferlin_C; Ferlin C-terminus

  11. XM_021699066.1 → XP_021554741.1  dysferlin isoform X7

    UniProtKB/TrEMBL
    A0A2Y9HT45
    Related
    ENSNSCP00000029221.1, ENSNSCT00000032863.1
    Conserved Domains (11) summary
    cd04011
    Location:220 → 329
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1155 → 1283
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:383 → 557
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1603 → 1726
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:8 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1837 → 1968
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:949 → 1005
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:790 → 862
    FerB; FerB (NUC096) domain
    pfam08151
    Location:327 → 377
    FerI; FerI (NUC094) domain
    pfam08165
    Location:701 → 758
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1981 → 2068
    Ferlin_C; Ferlin C-terminus

  12. XM_021699064.1 → XP_021554739.1  dysferlin isoform X5

    UniProtKB/TrEMBL
    A0A2Y9HXZ9
    Conserved Domains (11) summary
    cd04011
    Location:251 → 360
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1172 → 1300
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:414 → 574
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1599 → 1722
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1833 → 1964
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:966 → 1022
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:807 → 879
    FerB; FerB (NUC096) domain
    pfam08151
    Location:358 → 408
    FerI; FerI (NUC094) domain
    pfam08165
    Location:718 → 775
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1977 → 2064
    Ferlin_C; Ferlin C-terminus

  13. XM_021699060.1 → XP_021554735.1  dysferlin isoform X1

    UniProtKB/TrEMBL
    A0A2Y9HZH6
    Related
    ENSNSCP00000029202.1, ENSNSCT00000032843.1
    Conserved Domains (11) summary
    cd04011
    Location:251 → 360
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1172 → 1300
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:414 → 574
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1620 → 1743
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1854 → 1985
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:966 → 1022
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:807 → 879
    FerB; FerB (NUC096) domain
    pfam08151
    Location:358 → 408
    FerI; FerI (NUC094) domain
    pfam08165
    Location:718 → 775
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1998 → 2085
    Ferlin_C; Ferlin C-terminus

  14. XM_021699062.1 → XP_021554737.1  dysferlin isoform X3

    UniProtKB/TrEMBL
    A0A2Y9HT29
    Related
    ENSNSCP00000029215.1, ENSNSCT00000032856.1
    Conserved Domains (11) summary
    cd04011
    Location:251 → 360
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1186 → 1314
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:414 → 588
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1613 → 1736
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1847 → 1978
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:980 → 1036
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:821 → 893
    FerB; FerB (NUC096) domain
    pfam08151
    Location:358 → 408
    FerI; FerI (NUC094) domain
    pfam08165
    Location:732 → 789
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1991 → 2078
    Ferlin_C; Ferlin C-terminus
Nucleotide Protein
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