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DDX52 DExD-box helicase 52 [ Homo sapiens (human) ]

Gene ID: 11056, updated on 3-Apr-2024

Summary

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Official Symbol
DDX52provided by HGNC
Official Full Name
DExD-box helicase 52provided by HGNC
Primary source
HGNC:HGNC:20038
See related
Ensembl:ENSG00000278053 MIM:612500; AllianceGenome:HGNC:20038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROK1; HUSSY19
Summary
Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.2), endometrium (RPKM 4.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37609739..37643446, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38596713..38630405, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35969787..36003475, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene dual specificity phosphatase 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene synergin gamma Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210 Neighboring gene microRNA 378j Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36001021-36001522 Neighboring gene uncharacterized LOC105371756 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:36057789-36058988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36060550-36061050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36061051-36061551 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:36062200-36063399 Neighboring gene uncharacterized LOC124903989 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36068100-36068600 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:36070779-36071300 Neighboring gene HNF1 homeobox B Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:36071301-36071822 Neighboring gene uncharacterized LOC105371754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36083205-36083705

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc. Wang Q, et al. Bioengineered, 2021 Dec. PMID 34233596, Free PMC Article
  2. Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication - a targeted small interfering RNA library screen using pseudotyped and WT HIV-1. Williams CA, et al. J Gen Virol, 2015 Jun. PMID 25701821, Free PMC Article
  3. Characterization of 16 novel human genes showing high similarity to yeast sequences. Stanchi F, et al. Yeast, 2001 Jan 15. PMID 11124703
  4. The ribosome biogenesis factor yUtp23/hUTP23 coordinates key interactions in the yeast and human pre-40S particle and hUTP23 contains an essential PIN domain. Wells GR, et al. Nucleic Acids Res, 2017 May 5. PMID 28082392, Free PMC Article
  5. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Pharoah PD, et al. Nat Genet, 2013 Apr. PMID 23535730, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDX52 gene expression in LUAD tissues indicates potential as a prognostic biomarker and therapeutic target.
    Title: DDX52 gene expression in LUAD tissues indicates potential as a prognostic biomarker and therapeutic target.
  2. Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc.
    Title: Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
siRNA knockdown of DDX52 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag siRNA knockdown of DDX52 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX52
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEAD box protein 52
DEAD-box helicase 52
NP_001278405.1
NP_008941.3
XP_011522535.1
XP_054170786.1
XP_054185203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291476.2 → NP_001278405.1  probable ATP-dependent RNA helicase DDX52 isoform 2

    See identical proteins and their annotated locations for NP_001278405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC243585, AK001245, AK001652, AK025721, BX492013
    UniProtKB/TrEMBL
    B3KM65
    Conserved Domains (3) summary
    PRK11192
    Location:54 → 491
    PRK11192; ATP-dependent RNA helicase SrmB; Provisional
    cd00079
    Location:278 → 407
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:61 → 267
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_007010.5 → NP_008941.3  probable ATP-dependent RNA helicase DDX52 isoform 1

    See identical proteins and their annotated locations for NP_008941.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC243585, AK001245, AK025721, BC041785
    Consensus CDS
    CCDS11323.1
    UniProtKB/Swiss-Prot
    Q86YG1, Q8N213, Q9NVE0, Q9Y2R4, Q9Y482
    UniProtKB/TrEMBL
    Q59H21
    Related
    ENSP00000479504.1, ENST00000617633.5
    Conserved Domains (1) summary
    COG0513
    Location:136 → 599
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    37609739..37643446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524233.4 → XP_011522535.1  probable ATP-dependent RNA helicase DDX52 isoform X1

    UniProtKB/TrEMBL
    B3KM65
    Conserved Domains (3) summary
    COG0513
    Location:10 → 293
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:146 → 275
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cl21455
    Location:6 → 135
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1848852..1882540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329228.1 → XP_054185203.1  probable ATP-dependent RNA helicase DDX52 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    38596713..38630405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314811.1 → XP_054170786.1  probable ATP-dependent RNA helicase DDX52 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152300.2: Suppressed sequence

    Description
    NM_152300.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2R4.4 GenPept UniProtKB/Swiss-Prot:Q9Y2R4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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