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LOC110386951 CYP19A1 promoter II/1.3 [ Homo sapiens (human) ]

Gene ID: 110386951, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110386951
Gene description
CYP19A1 promoter II/1.3
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter, silencer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region encompasses multiple alternate promoters of the CYP19A1 (cytochrome P450 family 19 subfamily A member 1) gene, also known as aromatase. It contains a promoter region that can drive expression of a transgene in gonadal tissues, as well as multiple silencer elements. This region is induced by cyclic AMP and regulated by estrogen, leptin, calcitriol, retinoids, and prostaglandin. A hexameric nuclear receptor half-site motif binds members of the nuclear hormone receptor family, which regulate expression of this region in conjunction with nearby sites that bind cAMP responsive element binding protein 1, CCAAT/enhancer binding proteins, and AP-1 family transcription factors. [provided by RefSeq, Jun 2017]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51242868..51244050)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (49050640..49051822)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (51535065..51536247)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MIR4713 host gene Neighboring gene TNF alpha induced protein 8 like 3 Neighboring gene uncharacterized LOC124903492 Neighboring gene Sharpr-MPRA regulatory region 3311 Neighboring gene cytochrome P450 family 19 subfamily A member 1 Neighboring gene Sharpr-MPRA regulatory regions 2939 and 12041 Neighboring gene microRNA 4713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:51559063-51559696 Neighboring gene CYP19A1 promoter I.7 Neighboring gene uncharacterized LOC124903493 Neighboring gene microRNA 7973-2 Neighboring gene microRNA 7973-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls. Stueve TR, et al. BMC Pediatr, 2014 Mar 20. PMID 24649863, Free PMC Article
  2. HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma. Samarajeewa NU, et al. Breast Cancer Res, 2013 Apr 8. PMID 23566437, Free PMC Article
  3. Evaluation of a bioluminescent mouse model expressing aromatase PII-promoter-controlled luciferase as a tool for the study of endocrine disrupting chemicals. Rivest P, et al. Toxicol Appl Pharmacol, 2010 Nov 15. PMID 20723554
  4. The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells. Han EH, et al. Toxicol Lett, 2010 Oct 20. PMID 20678559
  5. Regulation of aromatase expression in breast cancer tissue. Bulun SE, et al. Ann N Y Acad Sci, 2009 Feb. PMID 19250199

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • CYP19A1 promoter I.3
  • CYP19A1 promoter I.6
  • CYP19A1 promoter II
  • aromatase P450 promoter II
  • aromatase promoter II/I.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055001.1 

    Range
    101..1283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    51242868..51244050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    49050640..49051822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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