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LOC110386949 CYP19A1 promoter I.7 [ Homo sapiens (human) ]

Gene ID: 110386949, updated on 10-Oct-2023

Summary

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Gene symbol
LOC110386949
Gene description
CYP19A1 promoter I.7
Gene type
biological region
Feature type(s)
protein_bind
regulatory: promoter
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region represents an alternate promoter of the the CYP19A1 (cytochrome P450 family 19 subfamily A member 1) gene, also known as aromatase. This promoter is induced by binding of GATA binding protein 2 and may be overexpressed in breast tumors. [provided by RefSeq, Jun 2017]
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Genomic context

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Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (51282182..51282561)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (49089953..49090332)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (51574379..51574758)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MIR4713 host gene Neighboring gene TNF alpha induced protein 8 like 3 Neighboring gene uncharacterized LOC124903492 Neighboring gene Sharpr-MPRA regulatory region 3311 Neighboring gene cytochrome P450 family 19 subfamily A member 1 Neighboring gene Sharpr-MPRA regulatory regions 2939 and 12041 Neighboring gene CYP19A1 promoter II/1.3 Neighboring gene microRNA 4713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:51559063-51559696 Neighboring gene uncharacterized LOC124903493 Neighboring gene microRNA 7973-2 Neighboring gene microRNA 7973-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CYP19A1, MIF and ABCA1 genes are targets of the RORα in monocyte and endothelial cells. Coban N, et al. Cell Biol Int, 2017 Feb. PMID 27925372
  2. Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue. Sebastian S, et al. Mol Endocrinol, 2002 Oct. PMID 12351690
  3. Regulation of breast cancer-associated aromatase promoters. Chen D, et al. Cancer Lett, 2009 Jan 8. PMID 18614276
  4. Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells. Watanabe M, et al. J Endocrinol, 2006 Jan. PMID 16394175
  5. The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters. Bulun SE, et al. J Steroid Biochem Mol Biol, 2003 Sep. PMID 14623514

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • aromatase promoter I.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055000.1 

    Range
    101..480
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    51282182..51282561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    49089953..49090332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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