U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC110351180 IBSP 5' regulatory region [ Homo sapiens (human) ]

Gene ID: 110351180, updated on 15-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
LOC110351180
Gene description
IBSP 5' regulatory region
Gene type
biological region
Feature type(s)
misc_feature: conserved_region
mobile_element
protein_bind
regulatory: CAAT_signal, TATA_box, promoter, silencer, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This record represents the promoter and related 5' regulatory region of the integrin binding sialoprotein gene, also known as BSP. The proximal promoter is highly conserved in mammals and is bound by runt related transcription factor 2, cAMP responsive element binding protein 1, and AP-1 family transcription factors. Activity of this promoter is induced by parathyroid hormone, platelet-derived growth factor, fibroblast growth factor 2, calcium hydroxide, interleukin 11, and melatonin, among other factors. This region includes an L1 retrotransposon-derived sequence that represses promoter activity. [provided by RefSeq, May 2017]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (87794552..87799702)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (91120983..91126133)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88715704..88720854)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900912 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 7 Neighboring gene integrin binding sialoprotein Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:88740127-88741326 Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:88786985-88787797 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:88813182-88814381 Neighboring gene heat shock protein 90 alpha family class B member 3, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Melatonin regulates human bone sialoprotein gene transcription. Matsumura H, et al. J Oral Sci, 2014 Mar. PMID 24739710
  2. Calcium hydroxide regulates bone sialoprotein gene transcription in human osteoblast-like Saos2 cells. Wang S, et al. J Oral Sci, 2011 Mar. PMID 21467818
  3. cAMP and fibroblast growth factor 2 regulate bone sialoprotein gene expression in human prostate cancer cells. Li Z, et al. Gene, 2011 Jan 15. PMID 20965237
  4. Regulation of human bone sialoprotein gene transcription by platelet-derived growth factor-BB. Mezawa M, et al. Gene, 2009 Apr 15. PMID 19393184
  5. CREB-1 and AP-1 transcription factors JunD and Fra-2 regulate bone sialoprotein gene expression in human breast cancer cells. Detry C, et al. Bone, 2008 Feb. PMID 18088579

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Homology

Other Names

  • bone sialoprotein promoter

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054764.1 

    Range
    101..5251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    87794552..87799702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    91120983..91126133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases