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POLY polyprotein;protein F [ Hepatitis C virus genotype 4 ]

Gene ID: 11027168, updated on 18-Aug-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein;protein F
Locus tag
HCV4_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Hepatitis C virus genotype 4 (subtype: 4a, isolate: ED43, nat-host: human; 33 years old)
Lineage
Viruses; Riboviria; Flaviviridae; Hepacivirus
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Genomic context

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Sequence:
NC_009825.1 (280..9306)

NC_009825.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009825.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of HCV genotype 4d infections in Kayseri, Turkey. Kayman T, et al. Turk J Med Sci, 2015. PMID 26281318
  2. The Core/E1 domain of hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma. Zhang X, et al. J Clin Virol, 2011 Dec. PMID 21925935, Free PMC Article
  3. Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East. Chamberlain RW, et al. J Gen Virol, 1997 Jun. PMID 9191927

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The frequency of genotype 4 hepatitis C virus (HCV) infections is significantly higher in Kayseri compared to other provinces in Turkey.
    Title: Characterization of HCV genotype 4d infections in Kayseri, Turkey.
  2. study concludes the Core/E1 domain of HCV genotype 4a in Egypt does not contain hepatocellular carcinoma -specific mutations or strains
    Title: The Core/E1 domain of hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
polyprotein;protein F
Names
core protein
E1 protein
E2 protein
p7 protein
NS2 protein
NS3 protease/helicase
NS4A protein
NS4B protein
NS5A protein
NS5B RNA-dependent RNA polymerase
YP_009272634.1
  • -2/+1 frameshift protein F; position predicted based on homology to protein F/predicted ribosomal slippage site in HCV1 RefSeq NC_004102.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009825.1 Reference assembly

    Range
    280..9306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001469632.1 polyprotein [Hepatitis C virus genotype 4]

    See identical proteins and their annotated locations for YP_001469632.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O39929
    UniProtKB/TrEMBL
    D6P446
    Conserved Domains (15) summary
    pfam01001
    Location:1728 → 1921
    HCV_NS4b; Hepatitis C virus non-structural protein NS4b
    pfam01539
    Location:195 → 382
    HCV_env; Hepatitis C virus envelope glycoprotein E1
    pfam01560
    Location:386 → 729
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1
    pfam01543
    Location:2 → 115
    HCV_capsid; Hepatitis C virus capsid protein
    pfam08301
    Location:2068 → 2168
    HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
    pfam01542
    Location:116 → 190
    HCV_core; Hepatitis C virus core protein
    pfam12941
    Location:2179 → 2417
    HCV_NS5a_C; HCV NS5a protein C-terminal region
    cl38915
    Location:1362 → 1486
    DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    pfam00998
    Location:2420 → 2931
    RdRP_3; Viral RNA dependent RNA polymerase
    pfam01006
    Location:1658 → 1711
    HCV_NS4a; Hepatitis C virus non-structural protein NS4a
    pfam01506
    Location:1975 → 1996
    HCV_NS5a; Hepatitis C virus non-structural 5a protein membrane anchor
    pfam01538
    Location:811 → 1005
    HCV_NS2; Hepatitis C virus non-structural protein NS2
    pfam02907
    Location:1057 → 1204
    Peptidase_S29; Hepatitis C virus NS3 protease
    pfam08300
    Location:2006 → 2067
    HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
    cl28899
    Location:1224 → 1366
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. YP_009272635.1 core protein

  3. YP_009272636.1 E1 protein

  4. YP_009272637.1 E2 protein

    Conserved Domains (1) summary
    pfam01560
    Location:3 → 346
    HCV_NS1; Hepatitis C virus non-structural protein E2/NS1

  5. YP_009272638.1 p7 protein

  6. YP_009272639.1 NS2 protein

  7. YP_009272640.1 NS3 protease/helicase

  8. YP_009272641.1 NS4A protein

  9. YP_009272642.1 NS4B protein

  10. YP_009272643.1 NS5A protein

  11. YP_009272644.1 NS5B RNA-dependent RNA polymerase

  12. YP_009272634.1 protein F [Hepatitis C virus genotype 4]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7U3RKF2, A0A859ASZ6
Protein Accession Links
GenPept Link UniProtKB Link
CAA72338.1

Gene LinkOut

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