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HFE homeostatic iron regulator [ Sus scrofa (pig) ]

Gene ID: 110261476, updated on 17-Aug-2024

Summary

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Official Symbol
HFEprovided by VGNC
Official Full Name
homeostatic iron regulatorprovided by VGNC
Primary source
VGNC:VGNC:88866
See related
Ensembl:ENSSSCG00000037682
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in kidney (RPKM 12.7), spleen (RPKM 8.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See HFE in Genome Data Viewer
Location:
chromosome: 7
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (20758604..20767004)

Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene H3 clustered histone 3, pseudogene Neighboring gene H1.2 linker histone, cluster member Neighboring gene H4 clustered histone 3 Neighboring gene H1.6 linker histone, cluster member

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_010449.5 Chromosome 7 Reference Sscrofa11.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transferrin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of iron ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to iron ion starvation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hereditary hemochromatosis protein
Names
hemochromatosis
hemochromatosis factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

    Range
    20758604..20767004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021098424.1 → XP_020954083.1  hereditary hemochromatosis protein isoform X1

    UniProtKB/TrEMBL
    A0A4X1VJN7, A0A8D0X5E5
    Conserved Domains (2) summary
    cd07698
    Location:215 → 305
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:27 → 210
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  2. XM_021098426.1 → XP_020954085.1  hereditary hemochromatosis protein isoform X3

    UniProtKB/TrEMBL
    A0A0B8RST0, A0A4X1VJZ5, A0A8D0K0W2
    Related
    ENSSSCP00000055771.2, ENSSSCT00000043020.3
    Conserved Domains (2) summary
    cd07698
    Location:215 → 306
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:27 → 210
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  3. XM_021098425.1 → XP_020954084.1  hereditary hemochromatosis protein isoform X2

    UniProtKB/TrEMBL
    A0A8D0K7X0, A0A8D0X5E5, A0A8D1ESY7
    Conserved Domains (2) summary
    cd07698
    Location:181 → 271
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:4 → 176
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

  4. XM_021098427.1 → XP_020954086.1  hereditary hemochromatosis protein isoform X4

    UniProtKB/TrEMBL
    A0A4X1VJP6, A0A8D0K0W2, A0A8D0K9D5
    Conserved Domains (2) summary
    cd07698
    Location:181 → 272
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:4 → 176
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
Nucleotide Protein
Heading Accession and Version

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