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Dgkg diacylglycerol kinase, gamma [ Mus musculus (house mouse) ]

Gene ID: 110197, updated on 2-Nov-2024

Summary

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Official Symbol
Dgkgprovided by MGI
Official Full Name
diacylglycerol kinase, gammaprovided by MGI
Primary source
MGI:MGI:105060
See related
Ensembl:ENSMUSG00000022861 AllianceGenome:MGI:105060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
90kDa; Dagk3; mKIAA4131; 2900055E17Rik; E430001K23Rik
Summary
Enables ATP-dependent diacylglycerol kinase activity. Involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and negative regulation of phospholipase C/protein kinase C signal transduction. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Orthologous to human DGKG (diacylglycerol kinase gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 10.5), frontal lobe adult (RPKM 4.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Dgkg in Genome Data Viewer
Location:
16 B1; 16 13.37 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22285318..22476051, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22466568..22657302, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40391 Neighboring gene STARR-seq mESC enhancer starr_40392 Neighboring gene STARR-seq mESC enhancer starr_40393 Neighboring gene G protein subunit gamma 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_40394 Neighboring gene STARR-seq mESC enhancer starr_40398 Neighboring gene STARR-seq mESC enhancer starr_40399 Neighboring gene STARR-seq mESC enhancer starr_40400 Neighboring gene STARR-seq mESC enhancer starr_40406 Neighboring gene ets variant 5 Neighboring gene STARR-positive B cell enhancer ABC_E394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:22498212-22498365 Neighboring gene RIKEN cDNA 9230117E06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:22545025-22545325 Neighboring gene mitochondrial import inner membrane translocase subunit Tim21 pseudogene Neighboring gene microRNA 8095 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene predicted gene 15651 Neighboring gene STARR-seq mESC enhancer starr_40415 Neighboring gene STARR-seq mESC enhancer starr_40416 Neighboring gene predicted gene, 41433 Neighboring gene STARR-positive B cell enhancer mm9_chr16:22633282-22633583 Neighboring gene STARR-seq mESC enhancer starr_40417 Neighboring gene microRNA 6362 Neighboring gene STARR-positive B cell enhancer ABC_E5532 Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 30416 Neighboring gene crystallin, gamma S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ. Tsumagari R, et al. eNeuro, 2020 Mar/Apr. PMID 32033984, Free PMC Article
  2. Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase γ independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase γ. Tanino F, et al. Mol Cell Biochem, 2013 Jan. PMID 23054194
  3. Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma. Zhang L, et al. J Hepatol, 2024 Jan. PMID 37838036
  4. Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behavior. Isozaki T, et al. J Neurochem, 2016 Aug. PMID 27167678
  5. Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. Yasuda S, et al. FEBS Lett, 2007 Feb 6. PMID 17254573

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.
    Title: Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma.
  2. DGKgamma Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCgamma.
    Title: DGKγ Knock-Out Mice Show Impairments in Cerebellar Motor Coordination, LTD, and the Dendritic Development of Purkinje Cells through the Activation of PKCγ.
  3. Precise Regulation of the Basal PKCgamma Activity by DGKgamma Is Crucial for Motor Coordination.
    Title: Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination.
  4. A novel morphological function of the C-terminal DGK-gamma catalytic region in filopodia formation, independent of its enzymatic activity.
    Title: Induction of filopodia-like protrusions in N1E-115 neuroblastoma cells by diacylglycerol kinase γ independent of its enzymatic activity: potential novel function of the C-terminal region containing the catalytic domain of diacylglycerol kinase γ.
  5. DGKgamma functions through its catalytic action as an upstream suppressor of Rac1 and has a role in lamellipodium/ruffle formation
    Title: Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4131

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diacylglycerol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phospholipase C/protein kinase C signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron development IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diacylglycerol kinase gamma
Names
88 kDa diacylglycerol kinase
DAG kinase gamma
DGK-gamma
diacylglycerol kinase, gamma 3
diacylglycerol kinase, gamma 90kDa
diglyceride kinase gamma
NP_001333602.1
NP_619591.1
XP_017172339.1
XP_017172340.1
XP_017172341.1
XP_036015627.1
XP_036015628.1
XP_036015629.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346673.1 → NP_001333602.1  diacylglycerol kinase gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI646503, AK083258, BB653405, BY724037, CT009627
    Consensus CDS
    CCDS84217.1
    UniProtKB/TrEMBL
    Q570Z5, Q8C413
    Related
    ENSMUSP00000023578.8, ENSMUST00000023578.14

  2. NM_138650.2 → NP_619591.1  diacylglycerol kinase gamma isoform 1

    See identical proteins and their annotated locations for NP_619591.1

    Status: VALIDATED

    Source sequence(s)
    AK013697, AK220294, BU700613, BY724037
    Consensus CDS
    CCDS28068.1
    UniProtKB/Swiss-Prot
    Q91WG7
    UniProtKB/TrEMBL
    Q570Z5
    Related
    ENSMUSP00000087371.4, ENSMUST00000089925.10
    Conserved Domains (8) summary
    TIGR00147
    Location:433 → 753
    TIGR00147; lipid kinase, YegS/Rv2252/BmrU family
    smart00109
    Location:333 → 374
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:575 → 749
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:433 → 554
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:269 → 318
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:176 → 245
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:177 → 241
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:5 → 172
    DAG_kinase_N; Diacylglycerol kinase N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22285318..22476051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316851.3 → XP_017172340.1  diacylglycerol kinase gamma isoform X2

    UniProtKB/TrEMBL
    Q570Z5
    Conserved Domains (5) summary
    smart00045
    Location:582 → 756
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:440 → 561
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:315 → 364
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:176 → 291
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:5 → 172
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. XM_017316850.3 → XP_017172339.1  diacylglycerol kinase gamma isoform X1

    UniProtKB/TrEMBL
    Q570Z5
    Conserved Domains (6) summary
    smart00109
    Location:379 → 420
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00045
    Location:621 → 795
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:479 → 600
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:315 → 364
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:176 → 291
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:5 → 172
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. XM_036159736.1 → XP_036015629.1  diacylglycerol kinase gamma isoform X6

    Conserved Domains (4) summary
    smart00045
    Location:340 → 514
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:198 → 319
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:56 → 129
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl08302
    Location:15 → 49
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_036159735.1 → XP_036015628.1  diacylglycerol kinase gamma isoform X5

    Conserved Domains (4) summary
    smart00045
    Location:379 → 553
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:237 → 358
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:56 → 129
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl08302
    Location:15 → 49
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_036159734.1 → XP_036015627.1  diacylglycerol kinase gamma isoform X4

    Conserved Domains (4) summary
    smart00045
    Location:425 → 599
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:283 → 404
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cl00040
    Location:102 → 175
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl08302
    Location:64 → 95
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_017316852.3 → XP_017172341.1  diacylglycerol kinase gamma isoform X3

    UniProtKB/TrEMBL
    Q570Z5
    Conserved Domains (6) summary
    smart00109
    Location:379 → 420
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    smart00046
    Location:479 → 600
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:315 → 364
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00051
    Location:176 → 291
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam14513
    Location:5 → 172
    DAG_kinase_N; Diacylglycerol kinase N-terminus
    cl02440
    Location:621 → 743
    DAGK_acc; Diacylglycerol kinase accessory domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WG7.1 GenPept UniProtKB/Swiss-Prot:Q91WG7

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