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Fdps farnesyl diphosphate synthetase [ Mus musculus (house mouse) ]

Gene ID: 110196, updated on 2-Nov-2024

Summary

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Official Symbol
Fdpsprovided by MGI
Official Full Name
farnesyl diphosphate synthetaseprovided by MGI
Primary source
MGI:MGI:104888
See related
Ensembl:ENSMUSG00000059743 AllianceGenome:MGI:104888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fdpsl1; mKIAA1293; 6030492I17Rik
Summary
Predicted to enable dimethylallyltranstransferase activity and geranyltranstransferase activity. Predicted to be involved in farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of cholesterol biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver E18 (RPKM 129.0), liver adult (RPKM 110.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fdps in Genome Data Viewer
Location:
3 F1; 3 39.01 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89000895..89009274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89093588..89101967, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene predicted gene, 24403 Neighboring gene STARR-seq mESC enhancer starr_08223 Neighboring gene STARR-positive B cell enhancer ABC_E1623 Neighboring gene STARR-positive B cell enhancer ABC_E2078 Neighboring gene RUN and SH3 domain containing 1 Neighboring gene predicted gene, 22935 Neighboring gene STARR-seq mESC enhancer starr_08224 Neighboring gene predicted gene, 29704 Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiac-specific deletion of FDPS induces cardiac remodeling and dysfunction by enhancing the activity of small GTP-binding proteins. Wang X, et al. J Pathol, 2021 Dec. PMID 34467534
  2. Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice. Yang J, et al. Cardiovasc Res, 2013 Mar 1. PMID 23180723
  3. Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice. Dai D, et al. Gene, 2018 Sep 25. PMID 29864496
  4. Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors. Fukuchi J, et al. Steroids, 2003 Sep. PMID 12957674
  5. A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction. Reilly JF, et al. Biochem J, 2002 Sep 1. PMID 12020352, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.
    Title: Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.
  2. Overexpression of FPPS aggravates myocardial ischemia/reperfusion injury in mice.
    Title: Overexpression of farnesyl pyrophosphate synthase increases myocardial ischemia/reperfusion injury in mice.
  3. Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.
    Title: Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice.
  4. identified a single putative direct repeat 4 (DR4) LXR response element in the FPS promoter isolated from immortalized murine astrocyte P11-5 cells
    Title: Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.
  5. novel role in fibroblast growth factor-mediated signal transduction
    Title: A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107162

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dimethylallyltranstransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dimethylallyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables geranyltranstransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables geranyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables geranyltranstransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in farnesyl diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in farnesyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in farnesyl diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in geranyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
farnesyl pyrophosphate synthase
Names
(2E,6E)-farnesyl diphosphate synthase
CR 39
FPP synthase
FPP synthetase
FPS
cholesterol-regulated 39 kDa protein
dimethylallyltranstransferase
farnesyl diphosphate synthase
farnesyl pyrophosphate synthetase
geranyltranstransferase
NP_001240680.1
NP_608219.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253751.1 → NP_001240680.1  farnesyl pyrophosphate synthase isoform 1

    See identical proteins and their annotated locations for NP_001240680.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC140468, BC048497, BE994006, BY144580, CJ082322
    UniProtKB/TrEMBL
    Q3TMB3, Q3US29, Q5M8R9
    Conserved Domains (2) summary
    pfam00348
    Location:117 → 378
    polyprenyl_synt; Polyprenyl synthetase
    pfam07462
    Location:72 → 144
    MSP1_C; Merozoite surface protein 1 (MSP1) C-terminus

  2. NM_134469.4 → NP_608219.1  farnesyl pyrophosphate synthase isoform 2

    See identical proteins and their annotated locations for NP_608219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BC048497, BE994006, CJ082244
    Consensus CDS
    CCDS17488.1
    UniProtKB/Swiss-Prot
    Q920E5
    UniProtKB/TrEMBL
    Q3TMB3, Q3US29, Q4FJN9, Q5M8R9
    Related
    ENSMUSP00000080531.9, ENSMUST00000081848.13
    Conserved Domains (1) summary
    pfam00348
    Location:50 → 311
    polyprenyl_synt; Polyprenyl synthetase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89000895..89009274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_180985.1: Suppressed sequence

    Description
    NM_180985.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920E5.1 GenPept UniProtKB/Swiss-Prot:Q920E5

Gene LinkOut

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